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Micro and Nanotechnologies in Engineering Stem Cells and Tissues

Micro and Nanotechnologies in Engineering Stem Cells and Tissues

IEEE Press Series on Biomedical Engineering

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Micro and Nanotechnologies in Engineering Stem Cells and Tissues

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eBook

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Beschreibung

Details

Einband

Gebundene Ausgabe

Erscheinungsdatum

04.06.2013

Herausgeber

Murugan Ramalingam + weitere

Verlag

John Wiley & Sons Inc

Seitenzahl

328

Beschreibung

Details

Einband

Gebundene Ausgabe

Erscheinungsdatum

04.06.2013

Herausgeber

Verlag

John Wiley & Sons Inc

Seitenzahl

328

Maße (L/B/H)

24.1/16.4/2 cm

Gewicht

687 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-118-14042-0

Weitere Bände von IEEE Press Series on Biomedical Engineering

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  • Micro and Nanotechnologies in Engineering Stem Cells and Tissues

  • Preface xiii

    Contributors xv

    1 Stem Cells and Nanotechnology in Tissue Engineering and Regenerative Medicine 1

    1.1 A Brief History of Tissue Engineering and Regenerative Medicine, 1

    1.2 Introduction to Stem Cells, 3

    1.3 Tissue Engineering and Regenerative Medicine Strategies, 5

    1.4 Nanotechnology in Regenerative Medicine and Tissue Engineering, 8

    1.5 Conclusions, 19

    2 Nanofiber Technology for Controlling Stem Cell Functions and Tissue Engineering 27

    2.1 Introduction, 27

    2.2 Fabrication of Nanofibrous Scaffolds by Electrospinning, 30

    2.3 Stem Cells: Type, Origin, and Functionality, 32

    2.4 Stem Cell-Nanofiber Interactions in Regenerative Medicine and Tissue Engineering, 35

    2.5 Conclusions, 44

    3 Micro- and Nanoengineering Approaches to Developing Gradient Biomaterials Suitable for Interface Tissue Engineering 52

    3.1 Introduction, 52

    3.2 Classification of Gradient Biomaterials, 54

    3.3 Micro- and Nanoengineering Techniques for Fabricating Gradient Biomaterials, 59

    3.4 Conclusions, 70

    4 Microengineered Polymer- and Ceramic-Based Biomaterial Scaffolds: A Topical Review on Design, Processing, and Biocompatibility Properties 80

    4.1 Introduction, 80

    4.2 Dense Hydroxyapatite Versus Porous Hydroxyapatite Scaffold, 85

    4.3 Property Requirement of Porous Scaffold, 86

    4.4 Design Criteria and Critical Issues with Porous Scaffolds for Bone Tissue Engineering, 88

    4.5 An Exculpation of Porous Scaffolds, 90

    4.6 Overview of Various Processing Techniques of Porous Scaffold, 92

    4.7 Overview of Physicomechanical Properties Evaluation of Porous Scaffold, 95

    4.8 Overview of Biocompatibility Properties: Evaluation of Porous Scaffolds, 104

    4.9 Outstanding Issues, 107

    4.10 Conclusions, 109

    5 Synthetic Enroutes to Engineer Electrospun Scaffolds for Stem Cells and Tissue Regeneration 119

    5.1 Introduction, 119

    5.2 Synthetic Enroutes, 125

    5.3 Novel Nanofibrous Strategies for Stem Cell Regeneration and Differentiation, 131

    5.4 Conclusions, 135

    6 Integrating Top-Down and Bottom-Up Scaffolding Tissue Engineering Approach for Bone Regeneration 142

    6.1 Introduction, 142

    6.2 Clinic Needs in Bone Regeneration Fields, 143

    6.3 Bone Regeneration Strategies and Techniques, 144

    6.4 Future Direction and Concluding Remarks, 151

    7 Characterization of the Adhesive Interactions Between Cells and Biomaterials 159

    7.1 Introduction, 159

    7.2 Adhesion Receptors in Native Tissue, 160

    7.3 Optimization of Cellular Adhesion Through Biomaterial Modification, 166

    7.4 Measurement of Cell Adhesion, 170

    7.5 Conclusions, 174

    8 Microfluidic Formation of Cell-Laden Hydrogel Modules for Tissue Engineering 183

    8.1 Introduction, 183

    8.2 Cell-Laden Hydrogel Modules, 184

    8.3 Cell Assay Systems Using Microfluidic Devices, 189

    8.4 Implantable Applications, 191

    8.5 Tissue Engineering, 194

    8.6 Summary, 198

    9 Micro- and Nanospheres for Tissue Engineering 202

    9.1 Introduction, 202

    9.2 Materials Classification of Micro- and Nanospheres, 204

    9.3 Applications of Micro- and Nanospheres in Tissue Engineering, 205

    9.4 Conclusions, 212

    10 Micro- and Nanotechnologies to Engineer Bone Regeneration 220

    10.1 Introduction, 220

    10.2 Nano-Hydroxyapatite Reinforced Scaffolds, 221

    10.3 Biodegradable Polymeric Scaffolds and Nanocomposites, 225

    10.4 Silk Fibers and Scaffolds, 227

    10.5 Summary, 231

    11 Micro- and Nanotechnology for Vascular Tissue Engineering 236

    11.1 Introduction, 236

    11.2 Conventional Vascular Grafts, 237

    11.3 Tissue-Engineered Vascular Grafts, 237

    11.4 Micro- and Nanotopography in Vascular Tissue Engineering, 238

    11.5 Micro- and Nanofibrous Scaffolds in Vascular Tissue Engineering, 241

    11.6 Microvascular Tissue Engineering, 246

    11.7 Conclusions, 253

    12 Application of Stem Cells in Ischemic Heart Disease 261

    12.1 Introduction, 261

    12.2 Adult Skeletal Myoblast Cells, 267

    12.3 Adult Bone Marrow-Derived Stem Cells, 269

    12.4 Type of Stem Cells Used to Treat Cardiac Diseases, 273

    12.5 Application, 277

    12.6 Other Developing Technologies in Cell Engineering, 282

    Acknowledgments, 293

    References, 293

    Index 303