Epithelial Anion Transport in Health and Disease The Role of the SLC26 Transporters Family
Fr. 150.00
inkl. MwStBeschreibung
Details
Format
Kopierschutz
Ja
Family Sharing
Nein
Text-to-Speech
Nein
Erscheinungsdatum
11.07.2006
Herausgeber
Derek J. Chadwick + weitere
Cl- absorption and HCO3- secretion are intimately associated
processes vital to epithelial function, itself a key physiological
activity. Until recently the transporters responsible remained
obscure, but a breakthrough occurred with the discovery of the
SLC26 transporters family. It is now clear that the SLC26
transporters have broad physiological functions since mutations in
several members are linked to a variety of diseases. This book
describes the properties of this family in detail, with
contributions from the leading global researchers in the field.
Complementary views from experts on other ion channels are offered
in the discussions, which make fascinating reading.
This family consists of at least 10 genes, each of which has
several splice variants. Most members of the family are expressed
in the luminal membrane of epithelial cells. Characterization of
anion transport by three members has revealed that all function as
Cl-/HCO3- exchangers, suggesting that SLC26 transporters are
responsible for the luminal Cl-/HCO3- exchange activity. The SLC26
transporters are activated by the CF transmembrane conductance
regulator and activate it in turn, leading to a model in which
these molecules act together to mediate epithelial Cl- absorption
and HCO3- secretion.
The book includes chapters on the transport of other molecules by
the SLC26 family, including oxalate in the kidney and sugars in
cochlear hair cells amongst others. It also describes recent
discoveries that most SLC26 transporters bind to scaffold proteins
and that they all contain a conserved domain predicted to
participate in protein-protein interactions. These suggest the
SLC26 transporters exist in complexes with other Cl- and HCO3-
transporters, and possibly other regulatory proteins. This book
explores the functional role of these interactions, leading to
better understanding of transepithelial fluid and electrolyte
secretion and the diseases associated with it.
processes vital to epithelial function, itself a key physiological
activity. Until recently the transporters responsible remained
obscure, but a breakthrough occurred with the discovery of the
SLC26 transporters family. It is now clear that the SLC26
transporters have broad physiological functions since mutations in
several members are linked to a variety of diseases. This book
describes the properties of this family in detail, with
contributions from the leading global researchers in the field.
Complementary views from experts on other ion channels are offered
in the discussions, which make fascinating reading.
This family consists of at least 10 genes, each of which has
several splice variants. Most members of the family are expressed
in the luminal membrane of epithelial cells. Characterization of
anion transport by three members has revealed that all function as
Cl-/HCO3- exchangers, suggesting that SLC26 transporters are
responsible for the luminal Cl-/HCO3- exchange activity. The SLC26
transporters are activated by the CF transmembrane conductance
regulator and activate it in turn, leading to a model in which
these molecules act together to mediate epithelial Cl- absorption
and HCO3- secretion.
The book includes chapters on the transport of other molecules by
the SLC26 family, including oxalate in the kidney and sugars in
cochlear hair cells amongst others. It also describes recent
discoveries that most SLC26 transporters bind to scaffold proteins
and that they all contain a conserved domain predicted to
participate in protein-protein interactions. These suggest the
SLC26 transporters exist in complexes with other Cl- and HCO3-
transporters, and possibly other regulatory proteins. This book
explores the functional role of these interactions, leading to
better understanding of transepithelial fluid and electrolyte
secretion and the diseases associated with it.
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