• Produktbild: Apoptotic Chromatin Changes
  • Produktbild: Apoptotic Chromatin Changes

Apoptotic Chromatin Changes

Fr. 243.00

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Beschreibung

Produktdetails

Einband

Set mit diversen Artikeln

Erscheinungsdatum

23.03.2009

Verlag

Springer Netherland

Seitenzahl

412

Maße (L/B/H)

24.1/16/2.9 cm

Gewicht

748 g

Auflage

2009 edition

Sprache

Englisch

ISBN

978-1-4020-9560-3

Beschreibung

Produktdetails

Einband

Set mit diversen Artikeln

Erscheinungsdatum

23.03.2009

Verlag

Springer Netherland

Seitenzahl

412

Maße (L/B/H)

24.1/16/2.9 cm

Gewicht

748 g

Auflage

2009 edition

Sprache

Englisch

ISBN

978-1-4020-9560-3

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Apoptotic Chromatin Changes
  • Produktbild: Apoptotic Chromatin Changes
  • I. DNA EMPIRE
    Summary
    Historical events leading to the recognition of core processes of genetic information
    RNA World
    Pre-RNA World
    Additional arguments supporting the RNA World hypothesis
    Basic principles of the transfer of genetic information
    Core information processes belonging to the DNA Empire
    When did DNA evolve?
    Molecular oxygen serving the transition from RNA World to DNA Empire
    Saturation of seawater with oxygen and development of oxygen atmosphere
    Advantage of oxygen production
    Oxygen the Janus faced molecule
    Protection of anaerobes from oxygen toxicity
    Free radical formation during the synthesis of deoxyribonucleotides
    Cellular responses to DNA damage
    Conceptual changes in gene stability
    Primary information on cytotoxicity obtained at DNA level
    Detection of genotoxic changes at the structural level of DNA
    Enzymatic detection of cellular lesions: too late
    Early detection of cytotoxicity: at DNA level
    Conclusions
    References
    II. STRUCTURAL ORGANIZATION OF DNA
    Summary
    Building blocks of nucleic acids
    Structure of nucleotides
    Nucleic acid bases
    Types
    Aromatic character, planar structure of nucleic acid bases
    Free nucleic acid bases
    Light absorption
    Apolar interactions
    Hypochrome, hyperchrome effect
    Major, minor and rare bases
    Base analogues
    Antimetabolites
    Sugar component of nucleotides
    Why ribose was selected as the sugar component of nucleic acids
    Criteria for sugar selection
    Phosphate as nucleotide component
    Bond types in nucleotides
    Nomenclature of bases, nucleosides and nucleotides
    Metabolism of nucleotides
    De novo biosynthesis
    Basic conception of biosynthesis
    Ribonucleotide biosynthesis
    Deoxyribonucleotide biosynthesis
    dNDP--dNTP conversion
    dUMP formation
    Thymidilate formation (dUMP--dTMP)
    Regulation of nucleotide biosynthesis
    Degradation of nucleotides
    Biosynthesis of coenzymes
    Tissue specific purine synthesis
    Function of nucleotides
    DNA structure
    Structural levels of DNA
    Primary structure of DNA
    Secondary DNA structures
    H-bonds
    B-DNA
    A-DNA
    Z-DNA
    Cruciform DNA
    Bent DNA structures
    Transition from right-handed to left-handed DNA
    Tetraplex (quadruplex) DNA
    Differences in the structure of DNA and RNA
    Tertiary structure of DNA (topology)
    Thermodinamic aspects of supercoiling
    Topoisomerases
    Models of gyrase action
    Sign inversion and torsional model of supercoiling
    Rotating model of negative supercoiling
    Topology of eukaryotic DNA
    Nucleosome, the supercoil analogue in eukaryotes
    Supranucleosomal (chromosomal) organization of DNA
    Early chromatin models
    Solenoid versus zig-zag model
    Possible fibril arrangements
    Hairpin model
    Plectonemic model of chromatin condensation
    Chromosomes of animal cells
    Eukaryotic genome size and DNA compaction
    Chromosome number
    Metaphase chromosomes
    Centromere and teleomere regions of chromosomes
    Variation in DNA content, C-value paradox
    Variation in chromosome number
    Karyotype, chromosome size
    Genetic linkage
    Physical mapping
    Sex chromosomes
    Chromosomal aberrations
    Genetic diversity
    Eukaryotic cell cycle
    Cytogenetics
    Genes
    Temporal and spatial order of gene replication
    DNA is replicated and repaired in several subphases
    References

    III. CHROMATIN CONDENSATION
    Summary
    Importance of chromatin condensation
    Active and inactive chromatin
    Euchromatin and heterochromatin
    Histone code hypothesis
    Chromosome arrangement in the nucleus
    Models of chromosome condensation
    Chromatin folding in the interphase nucleus is poorly understood
    Chromatin models
    Review of methodologies
    Methods to visualize chromosome condensation during the cell cycle
    Centrifugal elutriation
    Permeable cellsTe