List of contributors viii
Preface x
Section one: Epidemiology
Chapter 1 Epidemiology of non-ST-segment elevation acute coronary syndromes 3
David Hasdai and Alexander Battler
Section two: Pathophysiology
Chapter 2 Pathologic findings in acute coronary syndromes 11
Erling Falk
Chapter 3 Vascular biology of acute coronary syndromes 24
Lina Badimon
Section three: Clinical aspects of ACS
Chapter 4 Clinical aspects of acute coronary syndromes 43
Eugene McFadden
Chapter 5 Circulating biomarkers for risk stratification 52
Christopher Heeschen
Section four: Investigation in ACS
Chapter 6 Coronary angiography angioscopy and intravascular ultrasound in non-ST-segment elevation acute coronary syndromes 65
Eric Van Belle Christophe Bauters François Schiele and Michel E. Bertrand
Chapter 7 New coronary imaging in acute coronary syndrome 78
Pim J. de Feyter Evelyne Regar and Nico R.A. Mollet
Section five: Special groups of patients
Chapter 8 Acute coronary syndromes in specialgroups of patients 97
Piero O. Bonetti Michael J. Zellweger Christoph Kaiser and Matthias E. Pfisterer
Section six: Pharmacological treatment
Chapter 9 Antiischemic treatment (nitrates ss-blockers calcium antagonists) 109
David McCarty Colum G. Owens and A.A. Jennifer Adgey
Chapter 10 Antiplatelet therapies: aspirin thienopyridines and glycoprotein IIb/IIIa receptor inhibitors 116
Jaydeep Sarma and Keith A.A. Fox
Chapter 11 Antithrombin drugs: LMWH unfractionated heparin direct thrombin inhibitors 139
Raphaelle Dumaine and Gilles Montalescot
Chapter 12 Statin therapy in ACS 152
François Schiele
Section seven: Myocardial revascularization
Chapter 13 Percutaneous coronary interventions and stenting/CABG in non-ST-segment elevation acute coronary syndromes 165
Nicolas Meneveau and Jean-Pierre Bassand
Section eight: Therapeutic strategy
Chapter 14 Risk stratification and therapeutic strategy 187
Christian W. Hamm
Chapter 15 Indication for revascularization in non-ST-elevation acute coronary syndrome 199
Lars Wallentin
Chapter 16 Management of patients with nonamenable lesions for myocardialrevascul arization 211
Victor Legrand
Chapter 17 Non-ST-segment elevation coronary syndromes: European Society of Cardiology guidelines 225
Michel E. Bertrand
Chapter 18 Non-ST-segment elevation acute coronary syndromes: ACC/AHA guidelines 236
Pierre Théroux
Chapter 19 From guidelines to registries 248
Luigi Tavazzi
Section nine: Secondary prevention
Chapter 20 Secondary prevention after acute episode of patients presenting with nonpersistent ST-segment elevation 261
Michel E. Bertrand
Chapter 21 How to detect vulnerable plaque 270
Dirk Boese and Raimund Erbel
Chapter 22 Localversus systemic prevention treatment 281
Mario Togni and Bernhard Meier
Conclusions 294
Index 295
