Definitions and Clinical Risk Factors Marc Moss and B. Taylor Thompson Epidemiology of Acute Lung Injury: A Public Health Perspective Gordon D. Rubenfeld and Margaret J. Neff Radiographic Findings of the Acute Respiratory Distress Syndrome Philip C. Goodman and Desir'ee M. Qui"nones Pulmonary Pathology of ARDS: Diffuse Alveolar Damage Lester Kobzik and Lynette Sholl Pathogenesis of Acute Lung Injury: Experimental Studies Rebecca M. Baron and Mark A. Perrella Pathogenesis of Acute Lung Injury: Clinical Studies Benedict C. Creagh-Brown and Timothy W. Evans Apoptosis in the Pathogenesis and Resolution of Acute Lung Injury Gustavo Matute-Bello and Thomas R. Martin Pathogenesis of Ventilator-Induced Lung Injury Franco Valenza, James A. Frank, Yumiko Imai, and Arthur S. Slutsky Sepsis in the Acute Respiratory Distress Syndrome: Treatment Implications Arthur P. Wheeler and Todd W. Rice Transfusion-Related Acute Lung Injury Mark R. Looney and Ognjen Gajic Mechanisms of Fibroproliferation in Acute Lung Injury Danielle Morse and Carol Feghali-Bostwick Current Approaches and Recent Advances in the Genetic Epidemiology of Acute Lung Injury/Acute Respiratory Distress Syndrome Michelle NG Gong and David C. Christiani Gene Expression Profiling and Biomarkers in ARDS Judie Howrylak and Augustine M. K. Choi Resolution of Alveolar Edema: Mechanisms and Relationship to Clinical Acute Lung Injury Lorraine B. Ware and Michael A. Matthay Lung Vascular Dysfunction and Repair in Acute Lung Injury: Role of the Endothelial Cytoskeleton Gabriel D. Lang, Eddie T. Chiang and Joe G. N. Garcia Surfactant Therapy in the Acute Respiratory Distress Syndrome Roger G. Spragg and James F. Lewis Prone Position in ARDS Antonio Anzueto and Luciano Gattinoni Mechanical Ventilation in the Acute Respiratory Distress Syndrome Roy G. Brower and Laurent Brochard Fluid Therapy and HemodynamicMonitoring in Acute Lung Injury Carolyn S. Calfee, Naveen Gupta, and Michael A. Matthay Pathogenesis of Sepsis and Sepsis-Induced Acute Lung Injury Estelle S. Harris, Matthew T. Rondina, Hansj..org Schwertz, Andrew S. Weyrich, and Guy A. Zimmerman Cell-Based Therapy for Acute Lung Injury and Acute Respiratory Distress Syndrome Naveen Gupta, Jae-Woo Lee, and Michael A. Matthay Chemokines and Cytokines in ARDS Michael P. Keane, Emer Kelly, and Robert M. Strieter