Yaghoubi, S: Imaging PET Reporter Transgenes in Living Subje Methods for Non-invasive Monitoring of Therapeutic Transgene Expression in Mice and Humans Using Positron Emission Tomography Reporter Genes
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- Englisch ausgewählt
Fr. 120.00
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
01.02.2009
Verlag
VDMSeitenzahl
216
Maße (L/B/H)
22/15/1.3 cm
Gewicht
338 g
Sprache
Englisch
ISBN
978-3-639-11517-8
Non-invasive imaging of transgene expression should
soon play a critical role in gene and adoptive
cellular gene therapy clinical trials. Positron
emission tomography (PET) reporter genes (PRG)/probes
(PRP) are currently the most advanced technologies
available for imaging transgens in humans. PRGs can
be used to image the location, magnitude, and time
variation of the intensity of transgene expression
throughout the whole body of a patient. This can
eliminate the need for multiple biopsies, which are
potentially dangerous and yet do not provide a
complete picture of whole body transgene expression
at multiple time points. This dissertation provides
details of several studies on direct and indirect
imaging of therapeutic transgenes using multiple
PRG/PRP systems in mice. Furthermore, it includes the
details of the first study on the pharmacokinetics,
dosimetry, and safety of an imaging reporter probe in
humans. Finally, a complete background on alternate
methods of imaging transgene expression has been
provided, concluding with a discussion of potential
future applications of imaging in gene therapy.
soon play a critical role in gene and adoptive
cellular gene therapy clinical trials. Positron
emission tomography (PET) reporter genes (PRG)/probes
(PRP) are currently the most advanced technologies
available for imaging transgens in humans. PRGs can
be used to image the location, magnitude, and time
variation of the intensity of transgene expression
throughout the whole body of a patient. This can
eliminate the need for multiple biopsies, which are
potentially dangerous and yet do not provide a
complete picture of whole body transgene expression
at multiple time points. This dissertation provides
details of several studies on direct and indirect
imaging of therapeutic transgenes using multiple
PRG/PRP systems in mice. Furthermore, it includes the
details of the first study on the pharmacokinetics,
dosimetry, and safety of an imaging reporter probe in
humans. Finally, a complete background on alternate
methods of imaging transgene expression has been
provided, concluding with a discussion of potential
future applications of imaging in gene therapy.
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