Contents Dedication About the Editors Contributing AuthorsPreface Introduction Section I: BASIC PHYSIOLOGY Chapter 1 Intestinal MicroecologyMartin H. Floch, MD, MACG, FACP, AGAF Chapter 2 Intraluminal DefensesAilsa Hart, PhD and Siew C. Ng, PhD Chapter 3 Barrier Function and the Immune ResponseKaren L. Madsen, PhD Chapter 4 Probiotics and the Allergic ResponseErika Isolauri, MD, PhD; Samuli Rautava, MD, PhD; Kirsi Laitinen, PhD; and Seppo Salminen, PhD Chapter 5 Quantification and Identification of Probiotic Organismsin HumansIan M. Carroll, PhD; Tamar Ringel-Kulka, MD, MPH; and Yehuda Ringel, MD Chapter 6 Nutrients to Nourish the Organisms: Prebiotics and FiberHarry J. Flint, BSc, PhD and Sylvia H. Duncan, BSc, PhD Chapter 7 Fermentation and the Effects of Probiotics on Host MetabolismGeorge T. Macfarlane, BSc, PhD; Sandra Macfarlane, BSc, PhD;and Katie L. Blackett, BSc, PhD Chapter 8 Use of Probiotic Yogurts in Health and DiseaseMary Ellen Sanders, PhD and Daniel Merenstein, MD Chapter 9 Single and Multiple Probiotic Organisms in Therapy of DiseasePramod Gopal, PhD and Gerald W. Tannock, PhD Chapter 10 Development of Cultured Dairy Probiotic Food ProductsMiguel Freitas, PhD Section II: USE IN CLINICAL MEDICINE Chapter 11 Use of Probiotics and Prebiotics in ChildrenJose M. Saavedra, MD, FAAP and Anne M. Dattilo, PhD, RD, CDE Chapter 12 Neonatal Necrotizing EnterocolitisErika C. Claud, MD and W. Allan Walker, MD Chapter 13 The Role of Probiotics in Diarrheal DiseasesStefano Guandalini, MD Chapter 14 Probiotics and Their Role in Antibiotic-Associated Diarrhea and Clostridium difficile InfectionLaurel H. Hartwell, MD and Christina M. Surawicz, MD, MACG Chapter 15 Use of Probiotics in the Treatment and Prevention ofSurgical InfectionsNada Rayes, MD; Peter Neuhaus, PhD; and Daniel Seehofer, MD Chapter 16 Allergic DiseasesShira Doron, MD and Sherwood L. Gorbach, MD Chapter 17 Treatment of Ulcerative ColitisKaren Kroeker, MD, FRCP(C) and Levinus A. Dieleman, MD, PhD Chapter 18 Probiotic Treatment in CrohnÆs DiseaseKaren Kroeker, MD, FRCP(C) and Richard N. Fedorak, MD, FRCP(C) Chapter 19 Probiotics and PouchitisMario Guslandi, MD, FACG Chapter 20 Irritable Bowel SyndromeEamonn M. M. Quigley, MD, FRCP, FACP, FACG, FRCPI Chapter 21 Use of Probiotics in the Prevention and Treatment of Radiation EnteritisGiuseppe Famularo, MD, PhD; Vito Trinchieri, MD; Luciana Mosca, PhD; and Giovanni Minisola, MD Chapter 22 Probiotics and Helicobacter pyloriAdam S. Kim, MD Chapter 23 Probiotics in Liver DiseaseAdam S. Kim, MD and Anish Sheth, MD Chapter 24 Probiotics Use in Bacterial Vaginosis and Vulvovaginal CandidiasisPaola Mastromarino, PhD; Beatrice Vitali, PhD; and Luciana Mosca, PhD