Produktbild: The Evolution of Drug Discovery

The Evolution of Drug Discovery From Traditional Medicines to Modern Drugs

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

18.03.2011

Abbildungen

farbige Illustrationen, schwarz-weiss Illustrationen, Tabellen, schwarz-weiss

Verlag

Wiley-VCH

Seitenzahl

528

Maße (L/B/H)

24.6/17.9/3 cm

Gewicht

1184 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-3-527-32669-3

Beschreibung

Rezension

"This serves as an excellent companion to many of the popular medicinal chemistry and pharmacology books, and gives students additional insight into the contemporary drug discovery process." (Doody s, 16 March 2012)

"The text is well referenced and complete with chemical illustrations. . . Recommended. Upper-division undergraduates through professionals." (Choice, 1 October 2011)
"It can be used by students interested in the classic achievements and case stories of drug discovery, but also by more experienced scientists as a guiding overview on the field. Last but not least, it serves well as a compendium to industrial professionals in the field of biomedical and medicinal chemistry research." (ChemMedChem, 2011)

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

18.03.2011

Abbildungen

farbige Illustrationen, schwarz-weiss Illustrationen, Tabellen, schwarz-weiss

Verlag

Wiley-VCH

Seitenzahl

528

Maße (L/B/H)

24.6/17.9/3 cm

Gewicht

1184 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-3-527-32669-3

Herstelleradresse

Wiley-VCH GmbH
product_safety@wiley.com
Wiley-VCH GmbH, Boschstrasse 12, DE-69469 Weinheim

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  • Produktbild: The Evolution of Drug Discovery
  • Foreword

    Preface and Acknowledgment

     

    EVOLUTION OF DRUG DISCOVERY

    Antiquity

    Great Periods of Drug Discovery

    Vaccines

     

    THE FIRST SYNTHETIC DRUGS AND THE BIRTH OF CHEMOTHERAPY

    Aspirin, Phenacetin, and Paracetamol

    Discovery of Pyrazolones

    Cocaine and Local Anesthetics

    Barbiturates and Related Compounds

    Fathers of Chemotherapy

     

    FROM CASUAL OBSERVATIONS TO SYSTEMATIC SEARCH

    From Antihistamines to Antipsychotics and Antidepressants: The Origins of Psychopharmacology

    Benzodiazepines

    Structural Variations on Sulfanilamide

    Azoles as a Source of Antibacterials, Antifungals, and Antihelmintics

    The Long Fight Against Cancer

    Sildenafil - The First Inhibitor of Rectile Dysfunction

     

    NATURE AS A SOURCE OF DRUGS: DRUGS FROM NATURAL PRODUCTS

    Plant Sources: Derivatives and Related Drugs (Selected Examples)

    Animal Sources: Derivatives and Related Drugs

    Drugs from Microbiological Sources

    Drugs from Marine Origin: The Contribution of the Sea to the Therapeutic Arsenal

     

    RATIONALIZING THE DRUG DISCOVERY PROCESS

    Early Rational Drug Discovery Approaches: L-Dopa and L-Alpha-Methyldopa

    Receptor-Based Drug Discovery

    Antimetabolites in the Fight Against Bacteria, Viruses, and Cancer

    Cyclooxygenase(COX) Inhibitors

     

    STRUCTURE-BASED DRUG DISCOVERY

    Searching for the Ideal Antihypertensive Agent: Renin-Angiotensin-Aldosterone System (RAAS)

    HIV Protease Inhibitors

    Drugs Effective Against the Influenza Virus (the Flu)

    Fight Against Cancer

    New Avenues for the Development of Antidiabetic Agents. Dipeptidyl-Peptidase-IV Inhibitors: Sitagliptin and Vildaglptin

     

    BIOPHARMACEUTICALS

    Monoclonal Antibodies (MAbs)

    Recombinant DNA Technology (Genetic Engineering)

    Some Recombinant Protein Drugs

    Protein-Polyethyleneglycol (PEG) Conjugates (Protein PEGylation)

     

    DRUG DISCOVERY IN THE POSTGENOMIC ERA: CONCLUDING REMARKS

    Chemical/Genomic Strategy

    Summary