Produktbild: The Cell Biology of Stem Cells
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The Cell Biology of Stem Cells

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

13.08.2010

Herausgeber

Eran Meshorer + weitere

Verlag

Springer Us

Seitenzahl

229

Maße (L/B/H)

25.7/17/1.9 cm

Gewicht

621 g

Auflage

2010

Sprache

Englisch

ISBN

978-1-4419-7036-7

Beschreibung

Portrait

Eran Mes horer, PhD, is studying chromatin plasticity in embryonic and neuronal stem cells at the Department of Genetics at the Hebrew University of Jerusalem. He received his PhD in Molecular Neuroscience from the Hebrew University and conducted his post‑doctoral studies at the National Cancer Institute, NIH. His lab focuses on understanding pluripotency, differentiation and reprogramming from a chromatin perspective, taking both genome‑wide and single cell approaches. He is a member of the International Society for Stem Cell Research and holds the Joseph H. and Belle R. Braun Senior Lectureship in Life Sciences.

Kathrin Plath, PhD, is an Assistant Professor in the Department of Biological Chemistry at the University of California Los Angeles since 2004. After she received her PhD from the Humboldt University at Berlin in Germany, she was at the University of California San Francisco and the Whitehead Institute in Cambridge, MA for her postdoctoral studies. Dr. Plath’s main research interest is to understand how developmental cues induce changes in chromatin structure at the molecular level, and how these changes regulate cell fate decisions and gene expression in mammalian development. She is a member of the International Society for Stem Cell Research and of the editorial board of several stem cell journals.

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

13.08.2010

Herausgeber

Verlag

Springer Us

Seitenzahl

229

Maße (L/B/H)

25.7/17/1.9 cm

Gewicht

621 g

Auflage

2010

Sprache

Englisch

ISBN

978-1-4419-7036-7

Herstelleradresse

Springer-Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE

Email: ProductSafety@springernature.com

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  • Produktbild: The Cell Biology of Stem Cells
  • 1. Early Embryonic Cell Fate Decisions in the Mouse
    Yojiro Yamanaka and Amy Ralston
    Abstract
    Introduction
    Lineage Establishment and the Pre?stem Cell Program: Formation of the Blastocyst
    Lineage Maintenance and the Stem Cell Program: Beyond the Blastocyst
    The Second Lineage Decision: Subdividing the ICM
    Cell Signaling Regulates PE/EPI Specification
    Establishment and Modulation of Pluripotency in the EPI Lineage
    Conclusion
    2. Nuclear Architecture in Stem Cells
    Kelly J. Morris, Mita Chotalia and Ana Pombo
    Abstract
    Introduction
    Functional Compartmentalization of the ES Cell Nucleus
    Stem Cell Features of Other Nucleoplasmic Subcompartments
    Chromatin Features Characteristic of ES Cell Nuclei
    Conclusion
    3. Epigenetic Regulation of Pluripotency
    Eleni M. Tomazou and Alexander Meissner
    Abstract
    Introduction
    Epigenetic Modifications
    The Epigenome of ES Cells
    Conclusion
    4. Autosomal Lyonization of Replication Domains During Early Mammalian Development
    Ichiro Hiratani and David M. Gilbert
    Abstract
    Introduction
    Replication Timing Program: An Elusive Measure of Genome Organization
    An Evolutionarily Conserved Epigenetic Fingerprint
    Replication Timing as a Quantitative Index of 3?Dimensional Genome Organization
    Replication Timing Reveals An Epigenetic Transition: Autosomal Lyonization at the Epiblast Stage
    Replication Timing and Cellular Reprogramming: Further Support for Autosomal Lyonization
    Maintenance and Alteration of Replication Timing Program and Its Potential Roles
    Conclusion
    5. PRESERVATION OF GENOMIC INTEGRITY IN MOUSE EMBRYONIC STEM CELLS
    Peter J. Stambrook and Elisia D. Tichy
    Abstract
    Introduction and Historical Perspective
    Mutation Frequencies in Somatic Cells
    Protection of the Mouse ES Cell Genome
    Conclusion
    6. Transcriptional Regulation in Embryonic Stem Cells
    Jian?Chien Dominic Heng and Huck?Hui Ng
    Abstract
    Introduction
    Embryonic Stem Cells as a Model to Study Transcriptional Regulation
    Transcription Factors Governing ESC Pluripotency
    TranscriptionalRegulatory Network
    Technologies for Dissecting the Transcriptional Regulatory Network
    The Core Transcriptional Regulatory Network: Oct4, Sox2 and Nanog
    Expanded Transcriptional Regulatory Network
    Enhanceosomes: Transcription Factor Complex
    Integration of Signaling Pathways to Transcriptional Network
    Interface Between Transcriptional and Epigenetic Regulation
    Conclusion
    7. ALTERNATIVE SPLICING IN STEM CELL SELF?RENEWAL AND DIFERENTIATION
    David A. Nelles and Gene W. Yeo
    Abstract
    Introduction
    Introduction to Alternative Splicing
    Alternative Splicing of Genes Implicated in Stemness and Differentiation
    Genome?Wide Methods to Identify and Detect Alternative Splicing Events
    Regulation of Alternative Splicing by RNA Binding Proteins
    Conclusion and Perspectives
    8. MicroRNA Regulation of Embryonic Stem Cell Self?Renewal and Differentiation
    Collin Melton and Robert Blelloch
    Abstract
    Introduction: The Self?Renewal Program
    Embryonic Stem Cells
    miRNA Biogenesis and Function
    ESCC miRNAs Promote Self?Renewal
    miRNAs Induced during ESC Differentiation Suppress the Self?Renewal Program
    Regulatory Networks Controlling miRNA Expression
    miRNAs Can Promote or Inhibit Dedifferentiation to iPS Cells
    miRNAs in Somatic Stem Cells
    miRNAs in Cancer Cells
    Conclusion
    9. TELOMERES AND TELOMERASE IN ADULT STEM CELLS and PLURIPOTENT EMBRYONIC STEM CELLS
    Rosa M. Marión and Maria A. Blasco
    Abstract
    Introduction
    Regulation of Telomeres and Telomerase
    Role of Telomeres and Telomerase in Adult SC Compartments
    Telomeres and Telomerase Regulation During Reprogramming by SCNT
    Telomeres and Telomerase Regulation During iPS Cell Generation
    Telomerase Activation is Essential for the “Good” Quality of the Resulting iPS Cells
    Regulation of Telomere Reprogramming
    Conclusion
    10. X Chromosome Inactivation and Embryonic Stem Cells
    Tahsin Stefan Barakat and Joost Gribnau
    Abstract
    Introduction
    Cis Acting Factors in XCI
    Trans Acting Factors in XCI
    Counting and Choice
    Silencing and Maintenance of