Contributors vii
1. Introduction 1
Mihai D. Niculescu and Paul Haggarty
Part I: Fundamental Principles in Epigenetics
Section A: Epigenetic Mechanisms
2. DNA Methylation 13
Natalia V. Cucu
3. Chromatin Modifications 47
Sandra B. Hake
4. Roles of RNAi and Other Micro-RNAs in the Regulation of Epigenetic Processes 73
Muller Fabbri
5. Epigenetic Inheritance: Both Mitotic and Meiotic 87
Nina J. Kaminen-Ahola, Arttu I. Ahola, and Emma Whitelaw
Section B: Development Epigenetics
6. Developmental Epigenetics: Roles in Embryonic Development 107
Liliana Burlibas¿a and Lucian Gavrila
Section C: Epigenetic Mechanisms in Disease
7. Epigenetics, Nutrition, and Cancer 129
Amy R. Johnson
8. Metabolic Syndrome, Obesity, and Diabetes 145
Karen D. Corbin
9. Autoimmunity 165
Donna Ray and Raymond Yung
10. Cardiovascular Diseases 173
Aurelian Bidulescu and Methode Bacanamwo
Part II: Nutritional Status and Specific Nutrients
Section A: Maternal Nutrition and Fetal Development
11. Maternal Nutrition and Developmental Outcomes 193
Shannon L. Haley, Laurie J. Moyer-Mileur, Robert H. Lane, and Lisa A. Joss-Moore
Section B: Role of Specific Nutrients
12. Folate, Vitamin B12, and Vitamin B6 211
Patrick J. Stover
13. Dietary Choline, Betaine, Methionine, and Epigenetic Mechanisms Influencing Brain Development 225
Steven H. Zeisel
14. Epigenetic Regulation by Retinoids 241
Amandio Vieira
15. We Are What We Eat: How Nutritional Compounds Such As Isoflavones Shape Our Epigenome 249
Carlos M. Guerrero-Bosagna and Susan J. Clark
16. Isothiocyanates and Polyphenols 263
Nigel J. Belshaw and Ian T. Johnson
Section C: Macronutrient Intakes
17. The Effect of Maternal Macronutrient Intake on Phenotype Induction and Epigenetic Gene Regulation 275
Karen A. Lillycrop, Mark A. Hanson, and Graham C. Burdge
Section D: Environmental Exposures
18. Epigenetic Manifestation of Environmental Exposures 289
Dana C. Dolinoy, Olivia S. Anderson, and Laura S. Rozek
Section E: Epidemiology of Nutritional Epigenetics
19. Epigenetics, Nutrition, and Reproduction: Short- and Long-Term Consequences 311
Paul Haggarty
20. Nutrition, Epigenetics, and Cancer: An Epidemiological Perspective 329
Audrey Jung and Ellen Kampman
Index 345
