Produktbild: Evolutionary Biology

Evolutionary Biology Cell-Cell Communication, and Complex Disease

Fr. 139.00

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

21.02.2012

Verlag

John Wiley & Sons Inc

Seitenzahl

176

Maße (L/B/H)

26.1/18.2/1.7 cm

Gewicht

486 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-0-470-64720-2

Beschreibung

Zitat

"...the book offers the biology-savvy reader with interesting insights into the contribution of cell-cell interactions to the development and evolution of phenotypes. Given the technical nature of the subject, this book will have particular appeal among researchers and students of cellular and molecular biology and among evolutionary biologists interested in the pathways linking genes to phenotypes. In keeping with the complexity of the topic, there is much to digest here, and readers knowledgeable in these fields will find interesting food for thought." ( Quarterly Reviews in Biology , 1 July 2013)

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

21.02.2012

Verlag

John Wiley & Sons Inc

Seitenzahl

176

Maße (L/B/H)

26.1/18.2/1.7 cm

Gewicht

486 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-0-470-64720-2

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: GPSR Kontakt

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  • Produktbild: Evolutionary Biology
  • Preface xi

    About the Authors xiii

    1 THE CELLULAR ORIGIN OF VERTEBRATES 1

    The Origins of Unicellular Life on Earth 1

    Prokaryotes versus Eukaryotes 4

    Coevolution of traits 5

    Cholesterol Facilitates Lipid Rafts for Cell-Cell Communication 7

    The Endomembrane System 9

    The Cellular Mechanism of Evolution 10

    Why Evolve? 11

    Cell-Cell Communication and Aging 12

    2 REDUCING LUNG PHYSIOLOGY TO ITS MOLECULAR PHENOTYPES 17

    Hormonal Acceleration of Lung Development 17

    Neutral Lipid Traffi cking and Lung Evolution 19

    Other Examples of Cellular Cooperativity 23

    Summary 24

    3 A CELL-MOLECULAR STRATEGY FOR SOLVING THE EVOLUTIONARY PUZZLE 25

    Rationale for Cell-Molecular Evolution 25

    Mechanism of Mammalian Lung Development 28

    Avian Lung Structure-Function Relationship: The Exception that Proves the Rule 32

    Does Ontogeny Recapitulate Phylogeny? The Role of PTHrP in Lung Development 32

    Interrelationship between PTHrP, Development, Physiology, and Repair: Is Repair a Recapitulation of Ontogeny and Phylogeny? 33

    4 THE EVOLUTION OF CELL-CELL COMMUNICATION 35

    Cell-Cell Communication as the Mechanistic Basis for Evolutionary Biology 36

    The Darwinian Biologic Spacetime Continuum and Einstein's Vision of the Universe 37

    Reverse Engineering of Physiologic Traits as a Portal for Viewing Evolution 38

    Cell-Cell Communication as the Basis for the Evolution of Metazoans 41

    Understanding Lung Evolution from the Middle Out 42

    The Cell-Cell Communication Model of Lung Evolution Traces Contemporary Phenotypes Back to Ancestral Phenotypes 43

    Predictive Value of the Lung Cell-Cell Communication Model for Understanding the Evolution of Physiologic Systems 44

    Sexual Dimorphism of Lung Development: A Case Study in Cell-Cell Communication and Evolutionary Plasticity 46

    Androgen Affects the Expression of Growth Factors Involved in Lung Development 48

    Evidence for an Association between Steroid-Resistant/Responsive Phenotypes and Human Lymphocyte Antigen (HLA) Haplotypes 49

    5 HOW TO INTEGRATE CELL-MOLECULAR DEVELOPMENT, HOMEOSTASIS, ECOLOGY, AND EVOLUTIONARY BIOLOGY: THE MISSING LINKS 53

    Neutral Theory versus Intelligent Design 54

    Internal Selection Theory 54

    The Counterintuitive Nature of Physiology and Solution to the Dead Sea Scrolls Puzzle 57

    The Continuum from Microevolution to Macroevolution 58

    cis Regulation and Adaptive Evolution 69

    Evolution of cis Regulatory Mechanisms 70

    6 FROM CELL-CELL COMMUNICATION TO THE EVOLUTION OF INTEGRATED PHYSIOLOGY 75

    Cell-cell Signaling and Alveolar Development: A Reductionist Approach to the Evolution of Physiologic Traits 77

    An Integrated, Empiric, Middle-Out Approach to Physiology 79

    A Molecular Evolutionary Link between the Lung and the Kidney? 82

    The Berner Hypothesis and Emergence of the Adipocyte: The Evolutionary Origins of the Lipofi broblast 83

    Lung Biology as a Cipher for Evolution 85

    Do Stretch Effects on PTHrP Expression Reflect Its Role in Adapting to Gravity? 85

    Wolff's Law Works for Both Bone and Lung 88

    Functional Relationship between the External and Internal Environments 89

    An Evolutionary Vertical Integration of the Phylogeny and Ontogeny of the Thyroid 91

    7 EXPLOITING CELL-CELL COMMUNICATION ACROSS SPACETIME TO DECONSTRUCT EVOLUTION 95

    Somewhere between the Gene and the Phenotype Lies the Process of Evolution 98

    A Functional Genomic Approach to Evolution as an Example of Terminal Addition 100

    Seeking Deep Homologies in Lung Evolution 102

    Systems Biology Based on Cell-Cell Communication 105

    Vertical Integration of Leptin Signaling, Human Evolution, and the Trojan Horse Effect 108

    Leptin and Human Evolution: Food for Thought 109

    8 THE PERIODIC TABLE OF BIOLOGY 115

    The Prospect of a Periodic Table of Biology 115

    Cellular Cooperation Is Key 116

    Elemental Biology 118

    PTHrP as an Archetype 118

    Evolution as the Solution 119

    Ramping Up a Mathematical Model of Evolution 121

    The Anthropic Principle Results from the Evolution of Cell-Cell Interactions 124

    9 VALUE ADDED BY THINKING IN TERMS OF THE CELL-CELL COMMUNICATION MODEL FOR EVOLUTION 125

    This is Not a Just-So Story 126

    Beyond Genomics 128

    From Fat Cells to Integrated Physiology 128

    Molecular Homologies Distinguish between the Evolutionary Forest and Trees 129

    The Oxygen-Cholesterol-Surfactant-Membrane Connection 130

    Cholesterol Metabolism as the Data Operating System for Vertebrate Biology? 131

    Translation of Genomics into the Periodic Table for Biology 132

    Deep Homologies 134

    Selection Pressure for Cell-Cell Communication: The Key to Understanding Evolution 135

    10 CELL-CELL COMMUNICATION AS THE BASIS FOR PRACTICING CLINICAL MEDICINE 139

    Cell-Cell Communication Maintenance and Breakdown Represent Heath and Disease, Respectively 140

    Cell-Cell Communications as a Framework for Human Evolution 140

    Canalization, Decanalization, and the Holistic Approach to the Practice of Medicine 141

    Exploiting Lung Evolution to Prevent and Treat Chronic Lung Disease 141

    Lung Evolution Explains the Magic of Continuous Positive Airway Pressure 142

    The Paradox of Infecting the Lung in Order to Treat Lung Disease Caused by Infection 143

    Exploiting Lung Evolution to Prevent and Treat Smoking-Related Lung Damage 144

    The Trojan Horse Effect of Canalization 145

    Impetus for Evolutionary Science as an Integral Part of the Clinical Curriculum 146

    Application of Evolutionary Science to Bioethics 147

    Evolutionary Science, a Biologic Periodic Table, and a Unifi ed Theory of Biology 148

    Summary 149

    Name Index 151

    Subject Index 153