Genetic Immunization & Cytokine Immunomodulation Immune Response in Mice Genetically Immunized with Echinococcus granulosus AgB2 in Combination with Cytokine Genes
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- Englisch ausgewählt
Fr. 81.90
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
09.12.2011
Verlag
LAP LAMBERT Academic PublishingSeitenzahl
132
Maße (L/B/H)
22/15/0.9 cm
Gewicht
215 g
Auflage
1. Auflage
Sprache
Englisch
ISBN
978-3-8473-1239-0
In chronic parasitic infections, the interplay between the host and the parasite suggests immuno-suppressive mechanisms developed by the parasite. Echinococcus granulosus, a tiny tapeworm that among other helminthes, favors the induction of T helper type 2 responses which are less severe and less destructive than T helper type 1 responses. This study aimed at exploring the immune response generated in BALB/c mice using genetic immunization technology. Immuno-modulation by the co-delivery of different cytokine genes (IFN-¿, IL-12, IL-4) was also investigated. Immunization by antigen B or its second subunit (EgAgB8/2) revealed dominated T helper type 2 cytokine response, IgG3 humoral response, low splenocyte cell proliferation, and low CD8+ cell count. However, restored CD8+ cell count, high splenocyte cell proliferation, and high expression of IFN-¿ cytokine in IFN-¿ gene co-immunized mice indicates the efficiency of cytokine gene immuno-modulation in skewing the response toward T helper type 1.
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