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  • Produktbild: Calcium Handling in hiPSC-Derived Cardiomyocytes
  • Produktbild: Calcium Handling in hiPSC-Derived Cardiomyocytes

Calcium Handling in hiPSC-Derived Cardiomyocytes

Aus der Reihe SpringerBriefs in Stem Cells

Fr. 73.90

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

22.06.2012

Abbildungen

XII, 18 illus., 17 illus. in color., farbige Illustrationen, schwarz-weiss Illustrationen

Verlag

Springer Us

Seitenzahl

52

Maße (L/B/H)

23.5/15.5/0.4 cm

Gewicht

113 g

Auflage

2012

Sprache

Englisch

ISBN

978-1-4614-4092-5

Beschreibung

Rezension

From the reviews:

“The book presents a method to address one of the major safety issues currently limiting the clinical application of hiPSC-CMC by providing an approach to assess hiPSC-CMC maturity. It is most suitable for researchers working with both embryonic stem cell (ESC) and hiPSC derived cardiomyocytes. … this book has the potential to serve as a stepping stone towards the development of personalized in vitro models of cardiac tissue in addition to clinical applications.” (Christina A. Michael, Doody’s Review Service, October, 2012)

Zitat

From the reviews:"The book presents a method to address one of the major safety issues currently limiting the clinical application of hiPSC-CMC by providing an approach to assess hiPSC-CMC maturity. It is most suitable for researchers working with both embryonic stem cell (ESC) and hiPSC derived cardiomyocytes. ... this book has the potential to serve as a stepping stone towards the development of personalized in vitro models of cardiac tissue in addition to clinical applications." (Christina A. Michael, Doody's Review Service, October, 2012)

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

22.06.2012

Abbildungen

XII, 18 illus., 17 illus. in color., farbige Illustrationen, schwarz-weiss Illustrationen

Verlag

Springer Us

Seitenzahl

52

Maße (L/B/H)

23.5/15.5/0.4 cm

Gewicht

113 g

Auflage

2012

Sprache

Englisch

ISBN

978-1-4614-4092-5

Herstelleradresse

Springer-Verlag KG
Sachsenplatz 4-6
1201 Wien
AT

Email: GPSR Kontakt

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  • Produktbild: Calcium Handling in hiPSC-Derived Cardiomyocytes
  • Produktbild: Calcium Handling in hiPSC-Derived Cardiomyocytes

  • Calcium is crucial in governing contractile activities of myofilaments in cardiomyocytes, any defeats in calcium homeostasis of the cells would adversely affect heart pumping action. The characterization of calcium handling properties in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CMCs) is of significant interest and pertinent to the stem cell and cardiac regenerative field because of their potential patient-specific therapeutic use.

    Table of contents:

    Myocardial Infarction and Heart Failure.- Embryonic Stem Cells/ Pluripotent Stem Cells.- Human Induced Pluripotent Stem Cell (hiPSC)-derived Cardiomyocytes as a Source for Cardiac Regeneration.- Calcium Homeostasis in Cardiomyocytes.- Sarcoplasmic Reticulum (SR) Governs Maturity of Cardiomyocytes.- SR Junctional Proteins Play a Role in Calcium Flux Between Cytosol and SR.- Spatial and Temporal Ca2+ Wavefront Dictated by T-tubule Structure.- IP3-Mediated Calcium Release Contributes to Whole-Cell Calcium Transients.- Calcium Handling Properties of hES-derived Cardiomyocytes.- iPSC-derived Cardiomyocyte as A Potential Platform for Disease Modellig of Impaired Calcium-Handling Related Syndrome.- Measurement of Cytosolic [Ca2+] by Fluorescence Confocal Microscopy.- Excitation-Contraction (EC) Coupling Assessment.- Limitation and Future Studies.