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Produktbild: Essential Biochemistry

Essential Biochemistry

Fr. 320.00

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

04.01.2013

Verlag

John Wiley & Sons Inc

Seitenzahl

744

Maße (L/B/H)

28.2/21.6/2.8 cm

Gewicht

1662 g

Auflage

3. Auflage

Sprache

Englisch

ISBN

978-1-118-08350-5

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

04.01.2013

Verlag

John Wiley & Sons Inc

Seitenzahl

744

Maße (L/B/H)

28.2/21.6/2.8 cm

Gewicht

1662 g

Auflage

3. Auflage

Sprache

Englisch

ISBN

978-1-118-08350-5

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  • Produktbild: Essential Biochemistry
  • PART ONE FOUNDATIONS

    1 THE CHEMICAL BASIS OF LIFE 1

    1-1 What is Biochemistry? 2

    1-2 Biological Molecules 3

    1-3 Energy and Metabolism 10

    1-4 The Origin and Evolution of Life 14

    2 AQUEOUS CHEMISTRY 24

    2-1 Water Molecules form Hydrogen Bonds 25

    2-2 The Hydrophobic Effect 30

    2-3 Acid-Base Chemistry 33

    2-4 Tools and Techniques: Buffers 41

    PART TWO MOLECULAR STRUCTURE AND FUNCTION

    3 FROM GENES TO PROTEINS 51

    3-1 DNA Is the Genetic Material 52

    3-2 Genes Encode Proteins 61

    3-3 Genomics 65

    3-4 Tools and Techniques: Manipulating DNA 70

    4 PROTEIN STRUCTURE 87

    4-1 Proteins Are Chains of Amino Acids 89

    4-2 Secondary Structure: The Conformation of the Peptide Group 96

    4-3 Tertiary Structure and Protein Stability 99

    4-4 Quaternary Structure 107

    4-5 Tools and Techniques: Analyzing Protein Structure 108

    5 PROTEIN FUNCTION 121

    5-1 Myoglobin and Hemoglobin: Oxygen-Binding Proteins 122

    5-2 Structural Proteins 133

    5-3 Motor Proteins 144

    6 HOW ENZYMES WORK 158

    6-1 What Is an Enzyme? 159

    6-2 The Chemistry of Catalysis 162

    6-3 The Unique Properties of Enzyme Catalysts 171

    6-4 Some Additional Features of Enzymes 174

    7 ENZYME KINETICS AND INHIBITION 188

    7-1 Introduction to Enzyme Kinetics 189

    7-2 Derivation and Meaning of the Michaelis-Menten Equation 191

    7-3 Enzyme Inhibition 200

    8 LIPIDS AND MEMBRANES 220

    8-1 Lipids 221

    8-2 The Lipid Bilayer 227

    8-3 Membrane Proteins 230

    8-4 The Fluid Mosaic Model 233

    9 MEMBRANE TRANSPORT 241

    9-1 The Thermodynamics of Membrane Transport 242

    9-2 Passive Transport 246

    9-3 Active Transport 252

    9-4 Membrane Fusion 255

    10 SIGNALING 266

    10-1 General Features of Signaling Pathways 267

    10-2 G Protein Signaling Pathways 271

    10-3 Receptor Tyrosine Kinases 277

    10-4 Lipid Hormone Signaling 281

    11 CARBOHYDRATES 290

    11-1 Monosaccharides 291

    11-2 Polysaccharides 294

    11-3 Glycoproteins 299

    PART THREE METABOLISM

    12 METABOLISM AND BIOENERGETICS 308

    12-1 Food and Fuel 309

    12-2 Metabolic Pathways 314

    12-3 Free Energy Changes in Metabolic Reactions 323

    13 GLUCOSE METABOLISM 338

    13-1 Glycolysis 339

    13-2 Gluconeogenesis 354

    13-3 Glycogen Synthesis and Degradation 357

    13-4 The Pentose Phosphate Pathway 361

    14 THE CITRIC ACID CYCLE 370

    14-1 The Pyruvate Dehydrogenase Reaction 371

    14-2 The Eight Reactions of the Citric Acid Cycle 374

    14-3 Anabolic and Catabolic Functions of the Citric Acid Cycle 384

    15 OXIDATIVE PHOSPHORYLATION 394

    15-1 The Thermodynamics of Oxidation-Reduction Reactions 395

    15-2 Mitochondrial Electron Transport 399

    15-3 Chemiosmosis 408

    15-4 ATP Synthase 410

    16 PHOTOSYNTHESIS 420

    16-1 Chloroplasts and Solar Energy 422

    16-2 The Light Reactions 425

    16-3 Carbon Fixation 432

    17 LIPID METABOLISM 442

    17-1 Fatty Acid Oxidation 445

    17-2 Fatty Acid Synthesis 453

    17-3 Synthesis of Other Lipids 463

    18 NITROGEN METABOLISM 475

    18-1 Nitrogen Fixation and Assimilation 476

    18-2 Amino Acid Biosynthesis 480

    18-3 Nucleotide Biosynthesis 488

    18-4 Amino Acid Catabolism 494

    18-5 Nitrogen Disposal: The Urea Cycle 498

    19 REGULATION OF MAMMALIAN FUEL METABOLISM 509

    19-1 Integration of Fuel Metabolism 510

    19-2 Hormonal Control of Fuel Metabolism 515

    19-3 Disorders of Fuel Metabolism 520

    PART FOUR GENETIC INFORMATION

    20 DNA REPLICATION AND REPAIR 529

    20-1 DNA Supercoiling 530

    20-2 The DNA Replication Machinery 533

    20-3 Telomeres 540

    20-4 DNA Damage and Repair 543

    20-5 DNA Packaging 552

    21 TRANSCRIPTION AND RNA 561

    21-1 Transcription Initiation 563

    21-2 RNA Polymerase 571

    21-3 RNA Processing 576

    22 PROTEIN SYNTHESIS 590

    22-1 tRNA Aminoacylation 592

    22-2 Ribosome Structure 596

    22-3 Translation 599

    22-4 Post-translational Events 608

    GLOSSARY 617

    SOLUTIONS 629

    ANSWERS TO PRACTICE PROBLEMS PP-1

    ANSWERS TO CLINICAL CONNECTION

    QUESTIONS CC-1

    INDEX I-1