Chivate, N: Formulation and Optimization of Solid Dispersion Box-behnken Design - An effective tool in Solid Dispersion
-
- Englisch ausgewählt
Fr. 85.90
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
21.06.2012
Verlag
LAP LAMBERT Academic PublishingSeitenzahl
196
Maße (L/B/H)
22/15/1.2 cm
Gewicht
310 g
Sprache
Englisch
ISBN
978-3-659-15959-6
The objective of this study was to prepare and evaluate solid dispersion of poorly water soluble drug Telmisartan, a candidate mainly from the class II category of BCS classification, to increase solubility and for enhancement of bioavailability. The solid dispersions were prepared by physical mixture method using PEG 6000, Eudrajit L 100 and PVP K 30 as a carrier. A Box Behnken design has been applied to study the effect of independent variables i.e. PEG 6000, Eudrajit L 100 and PVP K 30 on dependent variables i.e. % Cumulative Drug Release and time required for cumulative drug release . Response surface plots and counter plots were drawn and optimum formulations were selected based on feasibility search method. Validation of optimized study performed using three confirmatory runs indicated very high degree of prognostic ability of response surface methodology, with mean percentage error as +0.02. Optimized solid dispersion formulations were prepared and its effect on % Cumulative Drug Release and time was evaluated. Optimized solid dispersions were evaluated for % CDR and Time for CDR, FTIR, DSC, SEM and in vitro drug release study.
Kundinnen und Kunden meinen
Verfassen Sie die erste Bewertung zu diesem Artikel
Helfen Sie anderen Kund*innen durch Ihre Meinung