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  • Produktbild: The Epstein-Barr Virus
  • Produktbild: The Epstein-Barr Virus

The Epstein-Barr Virus

Fr. 171.00

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

13.12.2011

Herausgeber

Epstein + weitere

Verlag

Springer Berlin

Seitenzahl

462

Maße (L/B/H)

24.4/17/2.7 cm

Gewicht

833 g

Auflage

Softcover reprint of the original 1st ed. 1979

Sprache

Englisch

ISBN

978-3-642-67238-5

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

13.12.2011

Herausgeber

Verlag

Springer Berlin

Seitenzahl

462

Maße (L/B/H)

24.4/17/2.7 cm

Gewicht

833 g

Auflage

Softcover reprint of the original 1st ed. 1979

Sprache

Englisch

ISBN

978-3-642-67238-5

Herstelleradresse

Springer-Verlag KG
Sachsenplatz 4-6
1201 Wien
AT

Email: GPSR Kontakt

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  • Produktbild: The Epstein-Barr Virus
  • Produktbild: The Epstein-Barr Virus
  • List of Contents.- 1 Introduction: Discovery and General Biology of the Virus.- A. Introduction.- B. Discovery of EBV.- C. General Biology.- 2 Morphology of the Virus and of Virus-Induced Cytopathologic Changes.- A. Introduction.- B. Virus Morphology.- C. Virus-Induced Cytopathologic Changes.- D. Comment.- 3 EB Virus-Induced Antigens.- A. Introduction.- B. Antigen Detection Methods.- C. Membrane Antigen.- D. The Early Antigen Complex.- E. The Viral Capsid Antigen.- F. The EBV Nuclear Antigen.- G. Lymphocyte-Detected Membrane Antigen.- H. Antigen Expression in EBV-Carrying Cell Lines.- I. Expression of EBV Antigens During the Viral Cycle.- 4 Seroepidemiology of the Virus.- A. Identification of EBV as a New Human Herpes Group Virus.- B. Serologic Association of EBV with Burkitt’s Lymphoma and Other Diseases.- C. The Seroepidemiology of Burkitt’s Lymphoma.- D. The Seroepidemiology of Nasopharyngeal Carcinoma.- E. The Seroepidemiology of Infectious Mononucleosis.- F. Seroepidemiologic Observations in Other Diseases.- G. Concluding Remarks.- 5 Biochemistry of the Virus and Its Effects on the Metabolism of Infected Cells.- A. Introduction: B Lymphocytes, the Natural Host of EBV.- B. Molecular Composition of EB Virions.- C. Biochemical Consideration of the Resident EBV DNA in Lymphoblastoid Cells.- D. Biochemical Events Leading to the Release of EBV DNA from Control of Host-Cell Mechanisms.- E. Biochemical Aspects of EBV DNA Replication and Transcription:.- F. Biochemical Properties of EBV Nuclear Antigen (EBNA).- G. Biochemical Aspects of Infection of Lymphoblastoid Cells and Leukocytes with EBV.- H. Transformation of Cells with DNA.- I. Discussion.- 6 Molecular Probes and Genome Homology.- A. General Introduction.- B. Technology.- C. What We Have Learned.- D. Prospects.- E. Unifying Concept.- 7 Biochemical Detection of the Virus Genome.- 8 The State of the Virus Genome in Transformed Cells and Its Relationship to Host Cell DNA.- A. Introduction.- B. Types of EBV-Transformed Cells.- C. Models for the Maintenance of Latent EBV Genomes in Transformed Cells.- D. First Experimental Evidence for Free, Nonintegrated EBV Genomes in Raji Cells.- E. Possible Forms of Free, Nonintegrated EBV Genomes.- F. Detailed Analysis of the Free, Nonintegrated EBV Genomes in Raji Cells.- G. Detection of EBV DNA Covalently Bound to Host DNA in Raji Cells.- H. State of the EBV Genomes in Other Cells.- I. Replication of the Latent EBV DNA in Transformed Cells.- J. Association of EBV DNA with Chromosomes.- K. The EBV Genome and the Evolution of Burkitt’s Lymphoma.- 9 Early Events in Transformation of Human Lymphocytes by the Virus.- A. Recognition and Adsorption.- B. Penetration of Virus.- C. Expression of Viral Information.- D. Integration of EBV Genomes.- E. Expression of Information from Integrated Genomes.- 10 Transformation by the Virus In Vitro.- A. Introduction.- B. General Description of Transformation.- C. Viral Characteristics.- D. Target Cells and Their Properties.- E. Infectivity Assays.- F. Virus-Cell Relationships.- G. Cellular Interactions.- H. Inhibition of Transformation.- I. Role of In Vitro Transformation by EBV in the Establishment of Lymphoblastoid Cell Lines in Primary Culture of Human Tissues.- J. Effects of EBV Transformation on Karyotype.- K. Conclusion.- 11 The Nature of Lymphoid Cell Lines and Their Relationship to the Virus.- A. Introduction.- B. Provisional Classifications of Hematopoietic Cell Lines.- C. “Spontaneous” Establishment of Permanent EBV-Carrying Lymphoid Cell Lines.- D. Markers for Clonality.- E. Phenotypic Characteristics of EBV-Carrying Lymphoid Cell Lines.- F. Chromosome Studies on EBV-Carrying Lymphoid Cell Lines.- G. Phenotypic Stability During Long-Term Cultivation.- H. EBV Genome-Negative Hematopoietic Cell Lines.- I. Concluding Remarks.- 12 Activation of the Viral Genome In Vitro.- A. Introduction.- B. Properties of Human Lymphoblastoid Cell Lines.- C. State of the Virus Genome in Lymphoblastoid Cells.- D. Spontaneous Activation.- E. Activation Induced by Chemicals.- F. Virus Expression in Hybrid Cells.- G. Concluding Remarks.- 13 The Virus as the Etiologic Agent of Infectious Mononucleosis.- A. Evidence for the Etiologic Role of EBV in Infectious Mononucleosis.- B. Implications of the Serologic and Virologic Observations in Infectious Mononucleosis.- C. Facts and Speculations Regarding Pathogenesis.- 14 The Relationship of the Virus to Burkitt’s Lymphoma.- A. Introduction.- B. Burkitt’s Lymphoma.- C. The Virus and African Burkitt’s Lymphoma.- D. Sporadic Burkitt’s Lymphoma.- E. Oncornaviruses and Burkitt’s Lymphoma.- F. Discussion.- 15 The Relationship of the Virus to Nasopharyngeal Carcinoma.- A. Introduction.- B. Histopathology.- C. EBV-Related Serology in Nasopharyngeal Carcinoma.- D. EBV Genomes in Nasopharyngeal Carcinoma.- E. Biologic Activity of Nasopharyngeal Carcinoma — Associated EBV.- F. Disease-Related Serologic Studies.- G. Concluding Remarks.- 16 Experimental Carcinogenicity by the Virus in Vivo.- A. Introduction.- B. Virus Factors in Tumorigenesis.- C. Host Factors in Experimental Carcinogenicity.- D. Pathology of the Experimental Disease.- E. EBV Genome in the Experimental Tumors.- F. EBV-Specific and Heterophil Antibody Responses of Experimentally Infected Animals.- G. Special Features of Transformed Marmoset Cells.- H. Significance of Experimental Carcinogenicity by EBV.- I. Future Work with EBV in Primates.- 17 Comparative Aspects: Oncogenic Animal Herpesviruses.- A. Introduction.- B. Herpesviruses of Cold-Blooded Animals.- C. Herpesviruses of Warm-Blooded Animals.- D. Conclusions.- 18 Demographic Studies Implicating the Virus in the Causation of Burkitt’s Lymphoma; Prospects for Nasopharyngeal Carcinoma.- A. Introduction.- B. Epidemiologic Characteristics of EBV Infection and of the Associated Tumors.- C. The IARC Prospective Study of Burkitt’s Lymphoma in Uganda and the Causative Role of the Virus.- D. Prospects for the Epidemiologic Approach in Nasopharyngeal Carcinoma.- E. Intervention as the Final Step in Proving Causality.- F. Conclusions.- 19 Vaccine Control of EB Virus-Associated Tumors.- A. Introduction.- B. EBV as the Cause of a Human Cancer.- C. A Vaccine to Prevent EBV Infection.- D. The Vaccine Prevention of EBV-Related Tumors.- E. Discussion.