Band 205
The CD4 Molecule Roles in T Lymphocytes and in HIV Disease
Aus der Reihe
Current Topics in Microbiology and Immunology
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Sprache:Englisch
Fr. 142.00
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
30.12.2011
Herausgeber
Dan R. LittmanVerlag
Springer BerlinSeitenzahl
182
Maße (L/B/H)
23.5/15.5/1.2 cm
Gewicht
312 g
Auflage
Softcover reprint of the original 1st ed. 1996
Sprache
Englisch
ISBN
978-3-642-79800-9
During the late 1970's the application of hybridoma technology led to an explosion in the discovery and characterization of proteins expressed at the surface of hematopoietic cells. The understanding of T lymphocyte biology benefited enormously from this advance and from newly developed techniques for obtaining clonal T cells. Application of these methodologies resulted in the identification of the clonally restricted T cell antigen receptors (TCRs) and of a number of other molecules expressed more broadly on T cells. Among these, the CD4 and CD8 glycoproteins stood out because they were differentially expressed on distinct functional subsets of T lymphocytes. Moreover, blocking studies with monoclonal antibodies sug gested a functional role for CD4 and CD8 in T cell responses to antigen. Shortly thereafter, it was shown that T helper cells were the primary targets for the human immunodeficiency virus (HIV) and that CD4 serves as the viral receptor on these cells. These findings fueled an intense interest in CD4 during the last decade, in the hope that understanding the molecular nature of the HIV-CD4 interaction could hold the key to controlling AIDS.
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