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Band 16

Apoptosis

Aus der Reihe Progress in Molecular and Subcellular Biology

Fr. 137.00

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

14.12.2011

Herausgeber

Y. Kuchino + weitere

Verlag

Springer Berlin

Seitenzahl

149

Maße (L/B/H)

23.5/15.5/1 cm

Gewicht

271 g

Auflage

Softcover reprint of the original 1st ed. 1996

Sprache

Englisch

ISBN

978-3-642-79852-8

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

14.12.2011

Herausgeber

Verlag

Springer Berlin

Seitenzahl

149

Maße (L/B/H)

23.5/15.5/1 cm

Gewicht

271 g

Auflage

Softcover reprint of the original 1st ed. 1996

Sprache

Englisch

ISBN

978-3-642-79852-8

Herstelleradresse

Springer-Verlag KG
Sachsenplatz 4-6
1201 Wien
AT

Email: GPSR Kontakt

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  • Produktbild: Apoptosis
  • Produktbild: Apoptosis
  • An Endonuclease Responsible for Apoptosis.- 1 Introduction.- 2 Results.- 3 Discussion.- References.- Cytopathic Feline Leukemia Viruses Cause Apoptosis in Hemolymphatic Cells.- Abstract.- 1 Introduction.- 2 Cytopathic Infections with FeLV-C in Vivo and Direct Induction of Apoptosis in T4 Cells by FeLV-C.- 3 Killing of Lymphocytes by FeLV-FAIDS/p61C and Associated Variants.- 4 FeLV-C-Related Nonregenerative Anemia: Potential Role for Apoptosis.- 5 FeLV Genes Important in Cytopathicity/Apoptosis Induction.- 5.1 General Remarks.- 5.2 T-Cell Killing.- 5.3 Erythroid Aplasias.- 6 Speculative Relationship to Endogenous Virus Recombinants and Importance Across Evolution.- 7 Regions of FeLV p15E Important in Immunosuppression.- 8 Other Types of Cytopathic Disease Seen in Viremic Cats Which Could Have an Apoptotic Basis.- 8.1 Enteritis.- 8.2 Infertility and Abortion.- 8.3 Neurologic Syndrome.- 9 So How Does FeLV Cause Apoptosis?.- 10 Other Retroviruses and Animal Viruses as Potential Causes of Apoptosis.- 10.1 Retroviruses that Behave as Superantigens.- 10.2 HIV and Other Lentiviruses.- 10.3 Chicken Anemia Virus.- References.- Neurotoxicity in Rat Cortical Cells Caused by N-Methyl-D-Aspartate (NMDA) and gp120 of HIV-1: Induction and Pharmacological Intervention.- Abstract.- 1 Introduction.- 2 Induction of Apoptosis in Rat Cortical Cells by HIV-1 gp120 or NMDA In Vitro.- 2.1 DNA Fragmentation and Cell Morphology After gp120 Treatment.- 2.2 Induction of Apoptosis in Cortical Cell Cultures by HIV-1 Particles.- 2.3 Increased Release of Arachidonic Acid from Neurons After Incubation with gp120.- 2.4 Inhibition of Arachidonic Acid Release by Phospholipase A2 Inhibitor.- 2.5 Induction of Apoptosis in Cortical Cell Cultures of NMDA.- 2.6 Influence of NMDA Antagonists on Arachidonic Acid Release.- 2.7 Arachidonic Acid Augments the NMDA-Caused DNA Fragmentation.- 3 Prevention of Apoptosis in Cortical Cells In Vitro by Memantine and Flupirtine.- 3.1 Memantine.- 3.2 Flupirtine.- 3.2.1 Prevention of NMDA or HIV-gp120-Induced Apoptosis in Cortical Cells by Flupirtine.- 3.2.2 Cytoprotective Effect of Flupirtine on Untreated Rat Cortical Cells.- 4 Conclusion.- 4.1 Cell Biological Findings.- 4.2 Pharmacological Interventions.- References.- Apoptosis of Mature T Lymphocytes: Putative Role in the Regulation of Cellular Immune Responses and in the Pathogenesis of HIV Infection.- Abstract.- 1 Apoptosis of Immature T Lymphocytes.- 2 Apoptosis of Mature T Lymphocytes.- 3 Apoptosis of T Lymphocytes Induced by Superantigens and Conventional Antigen.- 4 Apoptosis of Mature T Lymphocytes In Vivo and Ex Vivo.- 5 Role of T-Cell Apoptosis in HIV Pathogenesis.- 6 Concluding Remarks.- References.- bcl-2: Antidote for Cell Death.- Abstract.- 1 Introduction.- 2 Structure and Expression of the bcl-2 Gene.- 3 Biological Function of bcl-2: Apoptotic Death-Sparing Activity.- 4 Role of bcl-2 in the Immune System.- 4.1 bcl-2 in Lymphocyte Selection.- 4.2 Production of Autoimmune Disease.- 5 Role of bcl-2 in Neuronal Tissue.- 6 Role of bcl-2 in Lymphomagenesis.- 7 Role of bcl-2 in Other Systems.- 7.1 Virus Persistent Infection.- 7.2 Epithelial Cells.- 7.3 Morphogenesis.- 8 Analysis of bcl-2-Deficient Mice.- 9 Subcellular Localization of bcl-2: Multiple Membrane Locations.- 10 Biochemical Function of bcl-2 Protein.- 11 bcl-2 Related Genes and bcl-2 Associated Proteins.- 12 Epilogue.- References.- Apoptosis Mediated by the Fas System.- Abstract.- 1 Introduction.- 2 Fas, a Receptor for a Death Factor.- 2.1 Molecular Properties of Fas.- 2.2 Expression of Fas.- 3 Mutation in the Fas Gene of lpr-Mice.- 3.1 Chromosomal Gene for Fas.- 3.2 Insertion of an Early Transposable Element in Intron of Fas Gene in lpr-Mice.- 3.3 A Point Mutation in the Fas Gene of lprcg Mice.- 4 Fas-Mediated Apoptosis.- 4.1 Apoptosis In Vitro.- 4.2 Apoptosis In Vivo.- 4.3 Activation of Fas to Induce Apoptotic Signal.- 4.4 Apoptotic Signal Mediated by Fas.- 5 Fas Ligand, a Death Factor.- 5.1 Identification and Purification of Fas Ligand.- 5.2 Molecular Properties of the Fas Ligand.- 5.3 Expression of the Fas Ligand.- 6 Physiological Roles of the Fas System.- 6.1 Involvement of the Fas System in Development of T-Cells.- 6.2 Involvement of the Fas System in CTL-Mediated Cytotoxicity.- 6.3 Pathological Tissue Damage Caused by the Fas System.- 7 Perspectives.- References.- Myc-Mediated Apoptosis.- Abstract.- 1 Introduction.- 2 c-Myc-Mediated Apoptosis.- 3 s-Myc-Mediated Apoptosis.- 3.1 Structural Feature of the s-myc Gene.- 3.2 Structural Feature and Biological Functions of the s-Myc Protein.- 3.3 Expression of the s-myc Gene.- 3.4 s-Myc-Mediated Apoptosis.- 4 Escape from Myc-Induced Apoptotic Cell Death.- 5 Conclusions.- References.- Clusterin: A Role in Cell Survival in the Face of Apoptosis?.- Abstract.- 1 Introduction.- 2 Clusterin-a Widely Expressed Multifunctional Protein.- 3 Clusterin Gene Expression in Apoptotic Epithelial Tissues.- 4 Clusterin Gene Expression in the Thymus.- 5 Clusterin Gene Expression in Retinitis Pigmentosa (RP) Retina.- 6 Clusterin Expression During Degenerative Processes in the Brain.- 7 Conclusions and Perspectives.- References.