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Produktbild: Biological Basis of Oncologic Thermotherapy

Biological Basis of Oncologic Thermotherapy

Aus der Reihe Thermotherapy

Fr. 138.00

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

13.12.2011

Abbildungen

XI, 5 illus., schwarz-weiss Illustrationen

Herausgeber

Michel Gautherie

Verlag

Springer Berlin

Seitenzahl

169

Maße (L/B/H)

27/19.3/1.1 cm

Gewicht

421 g

Auflage

Softcover reprint of the original 1st ed. 1990

Sprache

Englisch

ISBN

978-3-642-74941-4

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

13.12.2011

Abbildungen

XI, 5 illus., schwarz-weiss Illustrationen

Herausgeber

Michel Gautherie

Verlag

Springer Berlin

Seitenzahl

169

Maße (L/B/H)

27/19.3/1.1 cm

Gewicht

421 g

Auflage

Softcover reprint of the original 1st ed. 1990

Sprache

Englisch

ISBN

978-3-642-74941-4

Herstelleradresse

Springer Nature Customer Service Center GmbH
Europaplatz 3
69115 Heidelberg
DE
ProductSafety@springernature.com

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  • Produktbild: Biological Basis of Oncologic Thermotherapy
  • 1 Biological Basis of Thermotherapy (With Special Reference to Oncology).- 1.1 Introduction.- 1.2 Methods of Hyperthermia Treatment.- 1.3 Heat Transfer to Tissues and Temperature.- 1.4 Biological Basis for the Action of Hyperthermia and of Combination with Ionizing Radiation.- 1.4.1 Mammalian Cell Survival After Exposure to Hyperthermia.- 1.4.2 Thermosensitivity of Normal and Malignant Cells.- 1.4.3 Cell Survival Dependent on the Cell Cycle.- 1.4.4 Modification of Cell Survival by the Microenvironment.- 1.4.5 Molecular and Metabolic Changes by Hyperthermia.- 1.4.5.1 Conformational Changes of Multimolecular Structures.- 1.4.5.2 Membranes.- 1.4.5.3 Mitotic Spindles and the Cytoskeleton.- 1.4.5.4 Inhibition of DNA, RNA, and Protein Synthesis.- 1.4.5.5 Glucose Metabolism and Hyperthermia.- 1.4.5.6 Redox Ratios and Hyperthermia.- 1.4.5.7 Oxygen Consumption, ATP Levels, and Hyperthermia.- 1.4.6 Thermotolerance.- 1.4.7 Combination of Hyperthermia and Ionizing Radiation.- 1.5 Mechanisms of Action in Cell Killing.- 1.5.1 Mechanisms of Action of Heat Alone.- 1.5.2 Mechanism of Action in Radiosensitization.- 1.6 Responses of Normal Tissues and Tumors.- 1.6.1 Responses of Normal Tissues to Heat.- 1.6.2 Thermoradiosensitization in Normal Tissues.- 1.6.3 Responses of Tumors to Heat.- 1.6.4 Radiosensitization by Heat in Tumors.- 1.7 Combination of Hyperthermia and Drugs.- 1.7.1 Alkylating Agents.- 1.7.2 Antibiotics.- 1.7.3 Antimetabolites.- 1.7.4 Vinca Alkaloids.- 1.7.5 Thermosensitizers.- 1.8 Conclusions.- References.- 2 Pathophysiological Mechanisms of Hyperthermia in Cancer Therapy.- 2.1 Effects of Hyperthermia on Blood Flow Rates and Microcirculation in Normal and Neoplastic Tissues.- 2.1.1 Normal Tissue Blood Flow upon Exposure to a Single Heating.- 2.1.2 Effect of Multiple Heatings on Normal Tissue Blood Flow.- 2.1.3 Laser Doppler Flowmetry in Normal Tissues During Localized Hyperthermia.- 2.1.4 Tumor Blood Flow During and After Hyperthermia.- 2.1.5 Effect of Multiple Heatings on Tumor Blood Flow Rate.- 2.1.6 Laser Doppler Flowmetry in Tumors During Localized Hyperthermia.- 2.1.7 Modification of Heat-Induced Changes in Timor Blood Flow.- 2.2 Microvascular Permeability in Tumors.- 2.2.1 Tumor Vascular Permeability During Normothermia.- 2.2.2 Tumor Vascular Permeability During Hyperthermia.- 2.3 Temperature Distribution in Tumors.- 2.3.1 Temperature Distribution in Tumors During Normothermia.- 2.3.2 Temperature Distribution in Neoplastic Tissues During Hyperthermia.- 2.4 Hyperthermia-Induced Changes in Nutrient and Oxygen Consumption Rates in Tumors.- 2.4.1 Nutrient and Oxygen Supply to Tumors During Hyperthermia.- 2.4.2 Oxygen and Glucose Uptake Rates by Tumors During Hyperthermia.- 2.4.3 Metabolic Imaging in Microregions of Tumors Using Bioluminescence and Photon Counting.- 2.4.4 Energy Status of Tumors upon Hyperthermia.- 2.5 Impact of Hyperthermia on the Cellular Microenvironment in Tumors.- 2.5.1 Tumor Tissue Oxygenation upon Hyperthermia.- 2.5.2 Impact of Localized Hyperthermia on the pH Distribution in Malignant Tumors.- 2.6 Effect of Hyperthermia on Intracellular Ion Concentrations.- 2.7 Conclusions.- References.- 3 The Heat Shock Response: Events Before, During, and After Gene Activation.- 3.1 Introduction.- 3.1.1 Scope of the Review.- 3.1.2 The Current State of Thermobiology.- 3.1.2.1 Heat Shock vs Temperature Shift.- 3.1.2.2 Thermotolerance vs Heat Resistance.- 3.1.2.3 Stress: At What Dose?.- 3.1.2.3.1 The Problem of Thermal and Other Dose.- 3.2 Events Before Gene Activation.- 3.2.1 The Thermotolerant Cell.- 3.2.1.1 Kinetics of Induction of Protection.- 3.2.2 Heat Resistance and Thermotolerance.- 3.2.3 The Cytoskeleton.- 3.2.4 Intracellular Species Unique to the Stressed Cell.- 3.2.4.1 Dinucleotides.- 3.2.4.2 Abnormal Proteins.- 3.2.5 Discussion.- 3.3 Events During and Immediately After Gene Activation.- 3.3.1 The Heat Shock Response at the DNA Level.- 3.3.1.1 Structure of the Heat Shock Genes and Regulation of the Heat Shock Response.- 3.3.1.2 Heat Shock Transcription Factor and Other Proteins Necessary for Transcription.- 3.3.2 The Heat Shock Proteins and Their Functions.- 3.3.2.1 The HSP 70 Family.- 3.3.2.2 The HSP 90 Family.- 3.3.2.3 Do HSPs Protect Cells Against Stress?.- 3.3.2.4 Stress-Induced Translocation of HSPs.- 3.4 Late Events.- 3.4.1 Heat Shock Response and Mitogenesis.- 3.4.2 Normal Development and Differentiation.- 3.4.2.1 Drosophila.- 3.4.2.2 Yeast.- 3.4.2.3 Protozoan Parasites.- 3.4.2.4 Induction of the Heat Shock Response in Early Embryos and in Undifferentiated Cells.- 3.4.2.5 Other Infectious Organisms.- 3.4.2.6 Humans.- 3.4.3 Abnormal Morphogenesis and Teratogenesis.- 3.4.3.1 Drosophila.- 3.4.3.2 Mammals (Nonhuman) and Birds.- 3.4.3.3 Humans.- 3.5 Conclusion.- References.