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  • Produktbild: Principles in General Pharmacology
  • Produktbild: Principles in General Pharmacology

Principles in General Pharmacology

Aus der Reihe Springer Series in Pharmacologic Science

Fr. 137.00

inkl. gesetzl. MwSt., Versandkostenfrei

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

22.09.2011

Verlag

Springer Us

Seitenzahl

243

Maße (L/B/H)

23.5/15.5/1.5 cm

Gewicht

400 g

Auflage

Softcover reprint of the original 1st ed. 1988

Sprache

Englisch

ISBN

978-1-4612-8346-1

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

22.09.2011

Verlag

Springer Us

Seitenzahl

243

Maße (L/B/H)

23.5/15.5/1.5 cm

Gewicht

400 g

Auflage

Softcover reprint of the original 1st ed. 1988

Sprache

Englisch

ISBN

978-1-4612-8346-1

Herstelleradresse

Springer-Verlag KG
Sachsenplatz 4-6
1201 Wien
AT

Email: GPSR Kontakt

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  • Produktbild: Principles in General Pharmacology
  • Produktbild: Principles in General Pharmacology
  • 1 General Principles: History and Overview.- Historical Perspective.- Principles.- Overview of Pharmacologic Principles.- References.- 2 Dose-Effect Relations.- Dose-Effect Graphs: Potency and Efficacy.- Antagonists.- Quantal (All-or-None) Dose-Response Relations.- Additivity and Synergism.- References.- 3 Pharmacokinetics.- Absorption.- Diffusion.- Rate Constant for Absorption.- Lipid-Water Partition Coefficient.- Transport Mechanisms.- Electrochemical Potential.- The Liver.- Drug Elimination.- Volume of Distribution.- Clearance.- Drug-Protein Binding.- Protein Binding and Disease.- Renal Excretion.- Glomerular Filtration.- Urine pH and Clearance.- Hepatic Clearance.- Intravenous Dosing.- Repeated Intravenous Injections.- Intravenous Infusion.- Absorption and Elimination.- Extravascular Multiple Dosing.- Time Course of Effect and Drug Receptor Concentration.- References.- 4 Drug Metabolism (Biotransformation).- General Principles.- Anatomical Sites of Biotransformation.- Biotransformation Reactions.- Factors Affecting Drug Metabolism.- Biotransformations of Selected Common Drugs.- References.- 5 Introduction to Specific Drug Action and Membrane Surface Phenomena.- Nonspecific Drug Action.- Specific Drug Action: The Development of the Concept of Receptors.- Coated Pits and Coated Vesicles.- Membrane Capping.- Conclusion.- References.- 6 Drugs and Receptors: Chemical Bonding.- General Principles.- Types of Bonds.- Bond Formation in the Drug-Receptor Interaction.- References.- Appendix A. Physical Constants.- Appendix B. Comparison of Atomic, Ionic, and Hydrated Radii of Some Chemical Elements.- Appendix C. Structures of Drug Groups.- 7 The Rate of Drug-Receptor Interactions.- Measuring the Rate of Chemical Reactions.- Rates of Equilibrium Reactions.- Rate of the Drug-Receptor Interaction.- Influence of Diffusion on Reaction Rate.- Suggested Reading.- 8 Pharmacodynamics: The Interaction of Drugs with Receptors.- Pharmacologic Receptors.- Formation of the Drug-Receptor Complex.- Classical Theory.- Alterations in Classical Drug-Receptor Theory and Alternative Approaches.- Dissociation Constants.- Drug Combinations: Isoboles.- A Changing Receptor Concentration: Modification of Rate Equations.- References.- 9 Radioligand Binding.- Direct Binding.- Analysis of Receptor Subtypes.- Radioligand-Binding Techniques.- References.- Appendix: Mathematical Tables.