Solid Dispersion Of Aceclofenac And B-Cyclodextrin Complex A Novel Approach For Treatment For Arthritic Pain
-
- Englisch ausgewählt
Fr. 67.90
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
13.07.2012
Verlag
LAP LAMBERT Academic PublishingSeitenzahl
92
Maße (L/B/H)
22/15/0.7 cm
Gewicht
155 g
Sprache
Englisch
ISBN
978-3-659-16194-0
Aceclofenac is an effective analgesic and anti-inflammatory drug prescribed widely in recent years for various types of pain and inflammation. Aceclofenac is partially insoluble in water and aqueous fluid and as such it exhibits poor variable oral bioavailability. Aceclofenac needs enhancement of solubility and dissolution rate to improve its oral bioavailability and therapeutic efficacy. Among the various approaches to enhance the solubility and dissolution rate of poorly soluble drugs complexation with cyclodextrin is an effective and industrially accepted technique. In the present investigation, Complexation of aceclofenac with ss-CD was carried out by using various techniques like physical mixture, kneading method, co-precipitate method & solvent evaporation method. From the various characterization studies like drug content, production yield & in vitro dissolution study. Data were further treated with statical analysis using ANNOVA model and from the result of statical analysis batch abc-6 by kneading method was selected as optimised batch. Optimised batch was also studied for FTIR and DSC studies.
Kundinnen und Kunden meinen
Verfassen Sie die erste Bewertung zu diesem Artikel
Helfen Sie anderen Kund*innen durch Ihre Meinung