Produktbild: Electroporation-Based Therapie

Electroporation-Based Therapie From Basics to Clinical Applications

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.01.2014

Herausgeber

Raji Sundararajan

Verlag

Elsevier LTD, Oxford

Seitenzahl

352

Maße (L/B/H)

24.1/16.1/2.5 cm

Gewicht

670 g

Sprache

Englisch

ISBN

978-1-907568-15-2

Beschreibung

Rezension

"...Key features include: Novel and recent clinical applications of electrochemotherapy for various cancers; An extensive study of a number of cell lines,.using both reversible and irreversible electroporation techniques..." --Anticancer Research

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.01.2014

Herausgeber

Raji Sundararajan

Verlag

Elsevier LTD, Oxford

Seitenzahl

352

Maße (L/B/H)

24.1/16.1/2.5 cm

Gewicht

670 g

Sprache

Englisch

ISBN

978-1-907568-15-2

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Die Leseprobe wird geladen.
  • Produktbild: Electroporation-Based Therapie
    • Dedication
    • Epigraph
    • List of figures and tables
      • Figures
      • Tables
    • Acknowledgments
    • About the editor
    • About the contributors
    • Introduction
      • Motivation:
      • Organization of the chapters
      • Audience
    • 1. Electrochemotherapy - A novel cancer treatment
      • Abstract:
      • 1.1 Why electrochemotherapy?
      • 1.2 References
    • 2. Clinical electrochemotherapy for chest wall recurrence from breast cancer
      • Abstract:
      • 2.1 Introduction
      • 2.2 Scope of the problem
      • 2.3 Treatment options for chest wall recurrence
      • 2.4 Clinical experience with electrochemotherapy
      • 2.5 Electrochemotherapy: the engineer's point of view
      • 2.6 Conclusions and perspectives
      • 2.7 Acknowledgments
      • 2.8 References
    • 3. Clinical electrochemotherapy for advanced superficial melanoma
      • Abstract:
      • 3.1 Introduction
      • 3.2 Therapeutic options in advanced melanoma
      • 3.3 Clinical experience with electrochemotherapy
      • 3.4 Conclusions and perspectives
      • 3.5 References
    • 4. Low and high voltage electrochemotherapy for breast cancer: an in vitro model study
      • Abstract:
      • 4.1 Introduction
      • 4.2 Anatomy of the breast and its cancer
      • 4.3 Drug delivery issues
      • 4.4 Chemotherapy issues
      • 4.5 Common adverse effects of anticancer drugs
      • 4.6 Anticancer drug resistance
      • 4.7 Electroporation and electrochemotherapy
      • 4.8 Materials and methods
      • 4.9 Results and discussion
      • 4.10 Conclusions
      • 4.11 Acknowledgments
      • 4.12 References
    • 5. Why electroporation is a useful technique for cancer treatments
      • Abstract:
      • 5.1 Introduction
      • 5.2 What is electroporation (EP)?
      • 5.3 Irreversible electroporation (IRE)
      • 5.4 Electrochemotherapy (ECT)
      • 5.5 Example of a hydrophilic agent used with electrochemotherapy
      • 5.6 Local delivery by intratumoral injection versus systemic administration in EP
      • 5.7 Prerequisites for effective ECT
      • 5.8 ECT can overcome multidrug resistance
      • 5.9 Intense nanosecond pulsed electric fields (nsPEFs)
      • 5.10 Electroporation therapies can produce a reduction in blood flow to tumors
      • 5.11 Properties of solid tumors
      • 5.12 Why do tumors have increased susceptibility to (EP) permeabilizing pulses, compared to that of normal tissue?
      • 5.13 Membrane composition and mineral concentrations of cancer cells affect the electrical properties
      • 5.14 Oxygen levels vary in solid tumors
      • 5.15 Glycolysis and pH
      • 5.16 Conclusions
      • 5.17 References
    • 6. Electrically-enhanced proliferation control of cancer-stem-cells-like adult human mesenchymal stem cells - a novel modality of treatment
      • Abstract:
      • 6.1 Introduction - stem cells
      • 6.2 Mesenchymal stem cells
      • 6.3 Cancer and cancer stem cells
      • 6.4 Electrochemotherapy
      • 6.5 In-vitro study of ECT on MSC
      • 6.6 Materials and methods
      • 6.7 Results and analyses
      • 6.8 Discussion and conclusions
      • 6.9 Future directions
      • 6.10 Acknowledgments
      • 6.11 References
    • 7. An in vitro study of electroporation of leukemia and cervical cancer cells
      • Abstract:
      • 7.1 Introduction
      • 7.2 Materials and methods
      • 7.3 Results and analysis
      • 7.4 Conclusions
      • 7.5 Acknowledgments
      • 7.6 References
    • 8. Low voltage nanosecond electroporation for breast cancer treatment: an in vitro study
      • Abstract:
      • 8.1 Introduction
      • 8.2 Materials and methods
      • 8.3 Results and analysis
      • 8.4 Discussion and conclusions
      • 8.5 Acknowledgment
      • 8.6 References
    • 9. Low and high voltage electroporation of in vitro human ovarian adenocarcinoma cells
      • Abstract:
      • 9.1 Introduction
      • 9.2 Materials and methods
      • 9.3 Results and analysis
      • 9.4 Discussion and summary
      • 9.5 Acknowledgments
      • 9.6 References
    • 10. Irreversible electroporation: a drug-free cancer treatment
      • Abstract:
      • 10.1 Introduction
      • 10.2 Materials and methods
      • 10.3 Results and analyses
      • 10.4 Discussion and conclusions
      • 10.5 Acknowledgments
      • 10.6 References
    • 11. Targeted delivery of siRNA and other difficult to transfect molecules using electroporation: current status and future scope
      • Abstract:
      • 11.1 Introduction
      • 11.2 siRNA - a potential therapeutic tool for cancer treatment
      • 11.3 siRNA-Gene targets in Cancer
      • 11.4 Delivery of siRNA
      • 11.5 Electroporation-based siRNA delivery
      • 11.6 Summary and Future Scope
      • 11.7 References
    • 12. Electric field distribution study of breast tumors
      • Abstract:
      • 12.1 Introduction
      • 12.2 Electric field concepts
      • 12.3 Electrical properties of cells
      • 12.4 Finite element modeling
      • 12.5 Electric field intensity used in clinical electrochemotherapy
      • 12.6 Electrodes used
      • 12.7 Thermal effects of electroporation
      • 12.8 Simulation
      • 12.9 Breast modeling
      • 12.10 Results and discussion
      • 12.11 Conclusions
      • 12.12 References
    • Index