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  • Produktbild: Immunopharmacology
  • Produktbild: Immunopharmacology
Band 3

Immunopharmacology

Aus der Reihe Comprehensive Immunology

Fr. 138.00

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

30.11.2012

Herausgeber

J. Hadden

Verlag

Springer Us

Seitenzahl

423

Maße (L/B/H)

25.4/20.3/2.4 cm

Gewicht

957 g

Auflage

Softcover reprint of the original 1st ed. 1977

Sprache

Englisch

ISBN

978-1-4615-7251-0

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

30.11.2012

Herausgeber

J. Hadden

Verlag

Springer Us

Seitenzahl

423

Maße (L/B/H)

25.4/20.3/2.4 cm

Gewicht

957 g

Auflage

Softcover reprint of the original 1st ed. 1977

Sprache

Englisch

ISBN

978-1-4615-7251-0

Herstelleradresse

Springer-Verlag KG
Sachsenplatz 4-6
1201 Wien
AT

Email: GPSR Kontakt

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  • Produktbild: Immunopharmacology
  • Produktbild: Immunopharmacology
  • 1 Cyclic Nucleotides in Lymphocyte Proliferation and Differentiation.- 1. Introduction.- 2. Cyclic Nucleotide Biochemistry.- 3. Hormonal and Pharmacological Modulation of Lymphocyte Proliferation.- 4. Cyclic Nucleotides in the Early Events of Mitogenic Action.- 5. Calcium in the Early Events of Mitogenic Action.- 6. Other Components of Mitogenic Action.- 7. Lymphocyte Nuclear Activation and Cyclic Nucleotides.- 8. Cyclic GMP and Calcium as the Intracellular Mitogen Signal.- 9. Hormone Induction of Thymocyte Differentiation.- 10. Cyclic Nucleotides in Thymocyte Differentiation.- References.- 2 Involvement of Cyclic Nucleotides as Intracellular Mediators in the Induction of Antibody Synthesis.- 1. Introduction.- 2. Induction and Paralysis.- 3. Effect of Cyclic Nucleotides on the Induction of Antibody Synthesis.- 4. Mitogen-Induced B-Lymphocyte Proliferation: Immunologic Effects.- 5. Cyclic Nucleotides and B-Lymphocyte Proliferation and Differentiation.- References.- 3 Regulation of Alloimmunity by Cyclic Nucleotides.- 1. Introduction.- 2. Cyclic Nucleotides.- 3. Pharmacological Abrogation of Target-Cell Lysis Mediated by Cytotoxic T Lymphocytes.- 4. Pharmacological Augmentation of Target-Cell Lysis Mediated by Cytotoxic T Lymphocytes.- 5. Pharmacological Abrogation of K-Cell-Mediated Lysis of Antibody-Coated Target Cells (Antibody-Dependent Lymphocyte-Mediated Cytotoxicity.- 6. Pharmacological Augmentation of K-Cell-Mediated Lysis by Cyclic GMP.- 7. Modulation of Graft-vs.-Host Proliferation by Cyclic Nucleotides.- 8. Modulation of Mixed Lymphocyte Culture Proliferation by Cyclic Nucleotides.- 9. Discussion.- References.- 4 Regulation of Polymorphonuclear Leukocyte, Macrophage, and Platelet Function.- 1. Introduction.- 2. Polymorphonuclear Leukocytes (Neutrophils).- 3. Mononuclear Phagocytes (Macrophages).- 4. Platelets.- 5. Summary and Conclusions.- References.- 5 Molecular Aspects of Macrophage Activation and Proliferation.- 1. Introduction.- 2. Macrophage Activation in Vivo.- 3. Macrophage Activation in Vitro.- 4. Mechanism of Action of Macrophage Mitogenic Factor.- 5. Lysosomal Enzyme Induction in the Mediation of Macrophage Activation.- 6. Other Mechanisms of Macrophage Activation.- 7. Summary.- References.- 6 Pharmacological Control of Mediator Release from Leukocytes.- 1. Introduction.- 2. General Properties of Histamine Release.- 3. Mechanism of Action of Antigen.- 4. The Phenomenon of Desensitization.- 5. Release of Mediators Other Than Histamine.- 6. Summary.- References.- 7 Generation, Function, and Disposition of Chemical Mediators of the Mast Cell in Immediate Hypersensitivity.- 1. Introduction.- 2. Generation and Release of Chemical Mediators.- 3. Characteristics of the Chemical Mediators.- 4. Modulation of Mediators of Immediate Hypersensitivity.- 5. Summary.- References.- 8 Plasma Factors: The Hageman-Factor-Dependent Pathways and the Complement Sequence.- 1. Introduction.- 2. Hageman-Factor-Dependent Pathways.- 3. Complement.- 4. Interactions with Other Mediator Systems.- 5. Pharmacological Modulation.- References.- 9 Prostaglandins in the Regulation of Immune and Inflammatory Responses.- 1. Introduction.- 2. Biological Function of the Prostaglandins.- 3. Inflammatory and Immunologic Diseases.- 4. Summary and Speculation.- References.- 10 Lymphokines: Physiologic Control and Pharmacological Modulation of Their Production and Action.- 1. Introduction: What Are Lymphokines?.- 2. Macrophage Migration-Inhibitory Factor (MIF).- 3. Macrophage Activation.- 4. Evidence for a Role of MIF in Vivo.- 5. Physiologic Control of MIF.- 6. Pharmacological Modulation of MIF.- 7. Physiologic Control and Pharmacological Modulation of Other Lymphokines.- 8. In Vivo Realities—Role of Lymphokines in Immunity and Nonimmunologic Processes.- References.- 11 Mechanism of Action of Antiallergic Drugs and Relationship of Cyclic Nucleotides to Allergy.- 1. Introduction.- 2. Cyclic Nucleotide Metabolism and Actions.- 3. Pathophysiology of Asthma.- 4. Drugs Used in Treatment of Asthma.- 5. Summary and Speculation.- References.- 12 Modulation of the Expression of the Immune Response by Antiinflammatory Drugs.- 1. Introduction.- 2. Effect of Antiinflammatory Agents on Lymphocytes and the Immune Response.- 3. Neutrophils.- 4. Macrophages.- 5. Conclusions.- References.- 13 Immunosuppressive Agents.- 1. Introduction and General Remarks.- 2. Steroids.- 3. Azathioprine and 6-Mercaptopurine.- 4. Cyclophosphamide.- 5. Other Chemical Immunodepressants and the Problem of Selective Immunosuppression.- 6. Nonspecific Biological Immunodepressants.- 7. Perspective for Immunologic Control.- References.- 14 Mechanisms of Immunopotentiation.- 1. Introduction.- 2. Biological Substances.- 3. Chemical Immunopotentiators.- 4. Products of the Immune System.- 5. Conclusions.- References.- 15 Immunoassay of Drugs and the Biological Use of Antidrug Antibodies.- 1. Introduction.- 2. Production of Antidrug Antibodies.- 3. Characterization of Antidrug Antibodies.- 4. Use of Antibodies in Immunoassays.- 5. Biological Properties of Antibodies to Drugs and to Other Compounds of Pharmacological Importance.- References.- 16 Receptors for Low-Molecular-Weight Hormones on Lymphocytes.- 1. Introduction.- 2. Determination of the ‘Physiologic’ Importance of Leukocyte Receptors.- 3. Somatic Genetic Analysis of Cyclic AMP Action as a Means of Assessing Receptor Function.- 4. Separation of Cells on the Basis of a Physiologic Function.- 5. Conclusions.- References.- 17 Polypeptide Hormone Receptors on Lymphoid Cells: Application to the Study of Receptor Alterations and Radioreceptor Assay of Polypeptide Hormones.- 1. Introduction.- 2. Existence of Insulin Receptors on Circulating Cells.- 3. Characteristics of the Insulin Receptor on Lymphoid Cells.- 4. Effects of Insulin on Lymphoid Cells.- 5. Existence of Human Growth Hormone (hGH) Receptors on Lymphoid Cells.- 6. Existence of Calcitonin Receptors on Human Lymphoid Cells.- 7. Radioreceptor Assay of Polypeptide Hormones Using Lymphoid Cell Receptors.- 8. Further Applications of Polypeptide Hormone Receptors on Lymphoid Cells.- 9. Conclusions.- References.- 18 Assays for Cyclic Nucleotides Including Clinical Applications.- 1. Introduction.- 2. Extraction, Purification, and Measurement of Cyclic Nucleotides.- 3. Clinical Applications.- References.