Glutamic Acid As Antineoplastic Agent A Synthetic And Biological Approach
-
- Englisch ausgewählt
Fr. 75.90
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
21.11.2014
Verlag
LAP LAMBERT Academic PublishingSeitenzahl
128
Maße (L/B/H)
22/15/0.9 cm
Gewicht
209 g
Sprache
Englisch
ISBN
978-3-659-64012-4
The investigation on glutamic acid analogs as possible antineoplastic agents started in the laboratories in the seventies. In continuation of this line of work several substituted amines were prepared and evaluated biologically. The main focus of this reaction work was to synthesize analogs of glutamic acid and look for their better antineoplastic activity. The structure of the synthesized compounds were confirmed and characterized with the help of IR, 1H-NMR, 13C-NMR, Mass spectra and elemental analysis. For the docking we have taken the protein Histone Deacetylase (HDAC) and identified the glutamic acid analogs that were used against Cancer. Here, out of 10 glutamic acid analogs, 6 better active analogs energy value was determined. The synthesized analogs were evaluated for their potential antineoplastic activity both in-vitro and in-vivo. The in-vitro activity was performed against five human cell lines like human breast cancer (MCF-7), leukemia (K-562), ovarian cancer (OVACAR-3), human colon adeno carcinoma (HT-29) and human kidney carcinoma (A-498). The in-vivo activity was performed in female Swiss Albino mice against Ehrlich Ascites Carcinoma (EAC).
Noch keine Bewertungen vorhanden
Verfassen Sie die erste Bewertung zu diesem Artikel
Helfen Sie anderen Kundinnen und Kunden durch Ihre Meinung.