Part I Challenges in Veterinary Vaccine Development
1. Challenges in Veterinary Vaccine Development and Immunization
Mark A. Chambers, Simon P. Graham, and Roberto M. La Ragione
Part II Vaccines for Farm Animals
2. Development of Mycoplasma hyopneumoniae Recombinant Vaccines
Silvana Beutinger Marchioro, Simone Simionatto, and Odir Dellagostin
3. Computational Prediction of Immunodominant Epitopes on Outer Membrane Protein (Omp) H of Pasteurella Multocida towards Designing of a Peptide Vaccine
Bhaskar Ganguly
4. DNA Vaccines against Maedi-Visna Virus
Ana M. Henriques, Miguel Fevereiro, and Gabriel A. Monteiro
5. Detection of Avian Antigen-Specific T cells Induced by Viral Vaccines
Tina Sørensen Dalgaard, Liselotte Rothmann Norup, and Helle Risdahl Juul-Madsen
6. Generation of Newcastle Disease Virus (NDV) Recombinants Expressing the Infectious Laryngotracheitis Virus (ILTV) Glycoprotein gB or gD as Dual Vaccines
Wei Zhao, Stephen Spatz, Laszlo Zsak, and Qingzhong Yu
7. A Reverse Genetics Approach for the Design of Methyltransferase-Defective Live Attenuated Avian Metapneumovirus Vaccines
Yu Zhang, Jing Sun, Yongwei Wei, and Jianrong Li
8. Development of Fasciola Vaccine in an Animal Model
Krai Meemon, and Pras
ert Sobhon
9. Development of Experimental Vaccines against Liver Flukes
Huan Yong Yap and Peter M. Smooker
10. Towards a Preventive Strategy for Toxoplasmosis: Current Trends, Challenges, and Future Perspectives for Vaccine Development
Ragab M. Fereig and Yoshifumi Nishikawa
11. DNA V
accination in Chickens
Shishir Kumar Gupta, Sohini Dey, and Madhan Mohan Chellappa
PART III Vaccines for Fishes and Shellfish
12. Selection of Vaccine Candidates for Fish Pasteurellosis Using a Reverse Vaccinology and an In Vitro Screening Approach
Francesca Andreoni, Giulia Amagliani, and Mauro Magnani
13. Development of Vaccines against Nocardia in Fishes
Sukanta K. Nayak and Teruyuki Nakanishi
14. Design of an Immersion Vaccine against Aeromonad Septicaemia in Perch (Perca fluviatilis L.).
Joachim Frey, Sarah E. Burr, and Thomas Wahli
15. Prokaryotic Production of Virus-Like Particle Vaccine of Betanodavirus
Junfeng Xie, Runqing Huang, and Yuxiong Lai
16. Design an
d Construction of Shrimp Antiviral DNA Vaccines Expressing Long and Short Hairpins for Protection by RNA Interference
Aparna Chaudhari, Gireesh Babu P, and A. Pavan Kumar
PART IV Vaccines against Ticks
17. Developing Anti-Tick Vaccines
Al
ina Rodríguez-Mallon
18. Host Immunization with Recombinant Proteins to Screen Antigens for Tick Control
Remil Linggatong Galay, Takeshi Miyata, Rika Umemiya-Shirafuji,
Masami Mochizuki, Kozo Fujisaki, and Tetsuya Tanaka
19. Vaccinomics Approach to Tick Vaccine Development
Marinela Contreras, Margarita Villar, Pilar Alberdi, and José de la Fuente
Part V Vaccine Adjuvants
20. Development of CpG ODN Based Vaccine Adjuvant Formulations
Mayda Gursel and Ihsan Gursel
Part VI Vaccine Vectors and Producti
on Systems
21. Assembly and Assessment of DNA Scaffolded Vaccines
Xiaowei Liu, Lili Wang, Hao Yan, and Yung Chang
22. Alphavirus-based Vaccines
Kenneth Lundstrom
23. Vaccine Design: Replication-Defective Adenovirus Vectors
Xiangyang Zhou, Zhiquan Xiang, and Hildegund C.J. Ertl
24. Generation of Lymphocytic Choriomeningitis Virus based Vaccine Vectors
Sandra Ring and Lukas Flatz
25. Production of Japanese Encephalitis Virus-like Particles Using Insect Cell Expression Systems
Hideki Yamaji and Eiji Konishi
26. Subunit Protein Vaccine Delivery System for Tuberculosis Based on Hepatitis B Virus Core VLP (HBc-VLP) Particles
Dhananjayan Dhanasooraj, Ajay Kumar R, and Sathish Mundayoor
27. Formulation Studies during Preclinical Development of Influenza Hemagglutinin and Virus-like Particle Vaccine Candidates
Newton Wahome, John M. Hickey, David B. Volkin, and C. Russell Middaugh
28. Strategies for Vaccine Design using Phage Display-Derived Peptides
Luiz R. Gou
lart and Paula de S. Santos
29. Production of Well-Characterized Virus-Like Particles in an Escherichia coli based Expression Platform for Preclinical Vaccine Assessments
Newton Wahome, Anne Cooper, Prem Thapa, Shyamal Choudhari, Fei P. Gao, David B. Volkin, and C. Russell Middaugh
30. Laboratory Scale Production of Recombinant Haa86 Tick Protein in Pichia pastoris and in Escherichia coli System
Binod Kumar, Azhahianambi P, and Ghosh Srikant
31. Production and Purification of Recombinant Filamentous Bacteriophages Displaying Immunogenic Heterologous Epitopes
Lei Deng, Florencia Linero, and Xavier Saelens
32. Oral Vaccine Development by Molecular Display Methods using Microbial Cells
Seiji Shibasaki and Mitsuyoshi Ueda
33. Facile Method for the Production of Recombinant Cholera Toxin B Subunit in E. Coli
Krystal Hamorsky and Nobuyuki Matoba
34. Immunoproteomic Approach for Screening Vaccine Candidates from Bacterial Outer Membrane Proteins
Jianyi Pan, Chuchu Li, and Zhicang Ye
35. Construction and Immunogenicity Testing of Whole Recombinant Yeast-Based T cell Vaccines
Thomas H. King, Zhimin Guo, Melanie Hermreck, Donald Bellgrau, and Timothy C. Rodell
36. Oral Rabies Vaccine Design For Expression in Plants
Ankit Singh, Gauri Saxena, and Praveen C. Verma
37. Purification of Virus-like Particles (VLPs) from Plants
Albertha R. van Zyl, and Inga I. Hitzeroth
38. Transient Expression of Viral Proteins in Plants using Agrobacterium tumefaciens
Inga I. Hitzeroth, and Albertha R. van Zyl
39. A Plant-Based Transient Expression System for the Rapid Production of Malaria Vaccine Candidates
Alexander Boes, Andreas Reimann, Richard M Twyman, Rainer Fischer, Stefan Schillberg, and Holger Spiegel
40. Recombinant Botulinum Toxoids: A Practical Guide for Production
Gustavo Marçal S.G. Moreira, Clóvis Moreira Jr., Carlos Eduardo P. da Cunha, Marcelo Mendonça, and Fabricio R. Conceição
41. Practical Approaches to Forced Degradation Studies of Vaccines
Manvi Hasija, Sepideh Aboutorabian, Nausheen Rahman, and Salvador F Ausar
PART VII Vaccine Delivery Systems
42. Preparation of Multifunctional Liposomes as a Stable Vaccine Delivery-Adjuvant System by Procedure of Emulsification-Lyophilization
Tin
g Wang, and Ning Wang
43. Preparation of the Multifunctional Liposome-Containing Microneedle Arrays as an Oral Cavity Mucosal Vaccine Adjuvant-Delivery System
Ting Wang, and Ning Wang
44. Preparation and Characterization of PLGA Encapsulated Protective Antigen Domain 4 Nanoformulation
Manish Manish, Rakesh Bhatnagar, and Samer Singh
45. Attenuated Salmonella sp. as a DNA Delivery Dystem for T. cruzi Antigens
Augusto E. Bivona, Natacha Cerny, Andrés Sánchez Alberti, Silvia I. Cazorla, and Emilio L. Malchiodi
46. Poly-e-Caprolactone/Chitosan and Chitosan Particles: Two Recombinant Antigen Delivery Systems for Intranasal Vaccination
Sandra Jesus, Edna Soares, and Olga Borges
47. Micro-Fractional Epidermal Powder Delivery for Skin Vaccination
Feng Jia, Shengwu Liu, Mei X. Wu, and Xinyuan Chen
Part VIII Vaccine Bioinformatics
48. A Bioinformatics Method for the Design of Live Attenuated Virus Vaccine Utilizing Host microRNA Response Elements
Duangdao Wichadakul
49. The Web-based DNA Vaccine Dat
abase DNAVaxDB and its Usage for Rational DNA Vaccine Design
Rebecca Racz and Yongqun He
50. MetaMHCpan, a Meta Approach for Pan-Specific MHC Peptide Binding Prediction
Yichang Xu, Cheng Luo, Hiroshi Mamits
uka, and Shanfeng Zhu
51. A Cohesive and Integrated Platform for Immunogenicity Prediction
Ivan Dimitrov, Mariyana Atanasova, Atanas Patronov, Darren R. Flower, and
Irini Doytchinova
Part IX Vaccine Safety and Regulation
52. The Regulatory Evaluation of Vaccines for Human Use
Norman W. Baylor
PART X Vaccine Intellectual Property
53. Vaccines and IP Rights: A Multifaceted Relationship
Karen Durell
54. From the Bench to the Pharmacy: Protecting Innovation during Vaccine Development and Commercialization
Adam C. Krol, Muna Abu-Shaar, and Paul Brady
55. Intellect
ual Property in Vaccine Innovation: Impact of Recent Patent Developments
Elizabeth Siew-Kuan Ng
