Effect of Metformin and Pioglitazone on Treatment of Psoriasis
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- Englisch ausgewählt
Fr. 51.90
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
13.01.2017
Verlag
LAP LAMBERT Academic PublishingSeitenzahl
56
Maße (L/B/H)
22/15/0.4 cm
Gewicht
102 g
Sprache
Englisch
ISBN
978-3-330-02945-3
Psoriasis vulgaris is a common, chronic, relapsing skin disease characterized by predominant involvement of skin, nails and joints. Recent advances in its pathophysiology have shifted the notion of psoriasis from that of a 'disease of the skin' to a 'T-cell mediated systemic disease'. Metformin acts as a modulator of the immune system, in psoriatic patients and has a remarkable effect on the early stages of psoriasis. The activation of PPAR-¿ by pioglitazone results in a reduction of the formation of the proinflammatory cytokines, and the inflammatory cells infiltration. These findings support the potential use of PPAR-¿ ligands as therapeutic agents in the therapy of conditions associated with autoimmune disease.
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