Computational Approaches for Identifying Drugs Against Alzheimer's Disease
-
- Taschenbuch ausgewählt
- eBook
-
Sprache:Englisch
Fr. 55.90
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
11.05.2017
Abbildungen
mit 27 Abbildungen
Verlag
Anchor Academic PublishingSeitenzahl
72
Maße (L/B/H)
22/15.5/0.5 cm
Gewicht
130 g
Auflage
1. Auflage
Sprache
Englisch
ISBN
978-3-96067-138-1
Alzheimer¿s disease is the most common form of dementia which is incurable. Although some kinds of memory loss are normal during aging, these are not severe enough to interfere with the level of function. ss-Secretase is an important protease in the pathogenesis of Alzheimer¿s disease. Some statine-based peptidomimetics show inhibitory activities to the ss-secretase. To explore the inhibitory mechanism, molecular docking and three-dimensional quantitative structure-activity relationship (3D-QSAR) studies on these analogues were performed. Quantitative structure-activity relationship (QSAR) modeling pertains to the construction of predictive models of biological activities as a function of structural and molecular information of a compound library. The concept of QSAR has typically been used for drug discovery and development and has gained wide applicability for correlating molecular information with not only biological activities but also with other physicochemical properties, which has therefore been termed quantitative structure-property relationship (QSPR). In this study, 3D QSAR and pharmacophore mapping studies were carried out using Accelrys Discovery Studio 2.1. The best nine drugs were selected from the 16 ligands and pharmacophore features were generated.
Kundinnen und Kunden meinen
Verfassen Sie die erste Bewertung zu diesem Artikel
Helfen Sie anderen Kund*innen durch Ihre Meinung