Computational Methods for GPCR Drug Discovery
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- Hardcover ausgewählt
- Taschenbuch
- eBook
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Sprache:Englisch
Fr. 192.00
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Gebundene Ausgabe
Erscheinungsdatum
30.11.2017
Abbildungen
XI, 111 illus., 102 illus. in color., farbige Illustrationen, schwarz-weiss Illustrationen
Herausgeber
Alexander HeifetzVerlag
Springer UsSeitenzahl
436
Maße (L/B/H)
26/18.3/3 cm
Gewicht
1012 g
Auflage
1st ed. 2018
Sprache
Englisch
ISBN
978-1-4939-7464-1
This volume looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics. The chapters in this book describe how these approaches can be applied to address key drug discovery issues, such as receptor structure modelling, function and dynamics, prediction of protein-water-ligand interactions and binding kinetics, free energy of binding, interconversion between agonists and antagonists, deorphanization of GPCRs, and the discovery of biased and allosteric modulators. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step, readily reproducible modelling protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and unique, Computational Methods for GPCR Drug Discovery is a valuable resource for structural and molecular biologists, computational and medicinal chemists, pharmacologists, and drug designers.
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