Part I: Overview
1. Experimental Models of Cardiovascular Diseases - Overview -
Jae Gyun Oh and Kiyotake Ishikawa
Part II :In Silico Models
2. An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity
Joshua Mayourian, Eric A. Sobie, and Kevin D. Costa
Part III: In Vitro Models
3. Isolation of Atrial and Ventricular Cardiomyocytes for In Vitro Studies
Jelena Plačkić and Jens Kockskämper
4. Cardiomyocyte Differentiation from mouse Embryonic Stem Cells
Adam T Lynch, Silvia Mazzotta, and Stefan Hoppler
5. Cardiomyocyte Differentiation from Human Embryonic Stem Cells
Silvia Mazzotta, Adam T Lynch, and Stefan Hoppler
6. Induction of Human Induced Pluripotent Stem Cells to Cardiomyocytes using Embryoid Bodies
Takeshi Hatani1, Kenji Miki, and Yoshinori Yoshida
7. Measuring Cardiomyocyte Contractility and Calcium Handling In Vitro
Przemek A. Gorski, Changwon Kho, and Jae Gyun Oh
Part IV: Ex Vivo Models
8. Langendorff Perfusion Method as an Ex Vivo Model to Evaluate Heart Function in Rats
Makino Watanabe and Takao Okada
9. Methods for the Preparation of an Excised, Cross-circulated Rat Heart
Koji Obata and Miyako Takaki
10. Optical Action Potential Mapping in Acute Models of Ischemia-reperfusion Injury: Probing the Arrhythmogenic Role of the Mitochondrial Translocator Protein
Zeki Ilkan, Benjamin Strauss, Chiara Campana, and Fadi G. Akar
11. Cardiac Tissue Engineering Models of Inherited and Acquired Cardiomyopathies
Irene C. Turnbull, Joshua Mayourian, Jack F. Murphy, Francesca Stillitano,
Delaine K. Ceholski, and Kevin D. Costa
12. Badimon Perfusion Chamber: An Ex Vivo Model of Thrombosis
M. Urooj Zafar, Carlos G. Santos-Gallego, Lina Badimon, and Juan J. Badimon,
Part V: Small Animal Models
13. Ischemic Model of Heart Failure in Rats and Mice
Jiqiu Chen, Delaine K. Ceholski, Irene C. Turnbull, Lifan Liang, and Roger J. Hajjar
14. Conventional Method of Transverse Aortic Constriction in Mice
Jimeen Yoo, Vadim Chepurko, Roger J. Hajjar, and Dongtak Jeong
15. Characterization of the Differential Progression of Left Ventricular Remodeling in a Rat Model of Pressure Overload Induced Heart Failure. Does Clip Size Matter?
Antoine H. Chaanine and Roger J. Hajjar
16. Isoproterenol-induced Heart Failure Mouse Model Using Osmotic Pump Implantation
Sunny C. Chang, Shuxun Ren, Christoph D. Rau, and Jessica J. Wang
17. Rat model of Cardiotoxic Drug Induced Cardiomyopathy
Takehiro Nakahara, Takashi Tanimoto, Artiom D. Petrov, Kiyotake Ishikawa, H. William Strauss, and Jagat Narula
18. Pulmonary Artery Hypertension Model in Rats by Monocrotaline Administration
Carlos Bueno-Beti, Yassine Sassi, Roger J. Hajjar, and Lahouaria Hadri
19. The Sugen 5416/Hypoxia Mouse Model of Pulmonary Arterial Hypertension
Carlos Bueno-Beti, Lahouaria Hadri, Roger J. Hajjar, and Yassine Sassi
20. Mouse Model of Wire Injury-Induced Vascular Remodeling
Aya Nomura-Kitabayashi and Jason C. Kovacic
21. The Mouse Aortocaval Fistula Model with Intraluminal Drug Delivery
Toshihiko Isaji and Alan Dardik
Part VI: Large Animal Models
22. A Pig Model Of Myocardial Infarction: Catheter Based Approaches
Olympia Bikou, Shin Watanabe, Roger J. Hajjar, and Kiyotake Ishikawa
23. Ovine Model of Ischemic Mitral Regurgitation
Dae-Hee Kim, Morris Brittan, J. Luis Guerrero, Suzanne M. Sullivan, Judy Hung, and Robert A. Levine
24. Canine Model of Pacing-induced Heart Failure
Jeffery C. Powers and Fabio Recchia
25. Swine Model of Mitral Regurgitation Induced Heart Failure
Shin Watanabe, Olympia Bikou, Roger J. Hajjar and Kiyotake Ishikawa
26. Pig Model of Increased Cardiac Afterload Induced by Ascending Aortic Banding
Olympia Bikou, Satoshi Miyashita, and Kiyotake Ishikawa
27. Large Porcine Model of Profound Acute Ischemic Cardiogenic Shock
Ole K. Møller-Helgestad, Hanne B. Ravn, and Jacob E. Møller
28. Chronic Pulmonary Artery Embolization Models in Large Animals
Jaume Aguero, Nadjib Hammoudi, Olympia Bikou, Kenneth M. Fish, Iratxe Zarragoikoetxea, Roger J. Hajjar, and Kiyotake Ishikawa
29. Modeling Pulmonary Hypertension: A Pig Model Of Post-capillary Pulmonary Hypertension
Olympia Bikou, Kiyotake Ishikawa, Kenneth M. Fish, Iratxe Zarragoikoetxea, Roger J. Hajjar, and Jaume Aguero
30. Development and Multiparametric Evaluation of Experimental Atherosclerosis in Rabbits
Max L. Senders, Mark E. Lobatto, Raphael Soler, Olivier Lairez, Carlos Pérez-Medina, Claudia Calcagno, Zahi A. Fayad, Willem J.M. Mulder, and Francois Fay
