Band 9
Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy
Aus der Reihe
Resistance to Targeted Anti-Cancer Therapeutics
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- Hardcover
- Taschenbuch ausgewählt
- eBook
-
Sprache:Englisch
Fr. 137.00
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
22.04.2018
Abbildungen
VIII, 27 illus., 19 illus. in color., schwarz-weiss Illustrationen, farbige Illustrationen
Herausgeber
Emmanuel DonnadieuVerlag
SpringerSeitenzahl
199
Maße (L/B/H)
23.5/15.5/1.2 cm
Gewicht
3226 g
Auflage
Softcover reprint of the original 1st ed. 2016
Sprache
Englisch
ISBN
978-3-319-82528-1
This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.
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