Produktbild: The Heterogeneity of Cancer Metabolism
Band 1063

The Heterogeneity of Cancer Metabolism

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Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

19.12.2018

Abbildungen

XV, 31 illus. in color., farbige Illustrationen

Herausgeber

Anne Le

Verlag

Springer

Seitenzahl

183

Maße (L/B/H)

23.5/15.5/1.2 cm

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-3-030-08525-4

Beschreibung

Portrait

Anne Le studied at the Paris Descartes University, Cochin Port-Royal School of Medicine, in France where she obtained a Habilitation degree (https://en.wikipedia.org/wiki/Habilitation), the highest academic qualification a scholar can achieve in Europe. After her clinical training at Henri Poincaré University Hospital, Nancy, in France, she started her postdoctoral research fellowship at the Johns Hopkins University School of Medicine in 2007. Since 2011, Dr. Le has been an independent investigator who has yielded a number of contributions to the field of cancer metabolism, demonstrated by her publication record as a pioneer in the field. She has published in the best journals, such as Cell Metabolism and the Proceedings of the National Academy of Sciences of the United States of America. Dr. Le has been invited to present her work at several annual American Association for Cancer Research meetings, the most prestigious international meeting for cancerresearch scientists and professionals, as well as by the National Cancer Institute, and universities in France, Monaco, Japan, and Taiwan. Research media, such as Science Daily, American Association for the Advancement of Science (AAAS), Business Insider, ALN® Magazine, among many others, have written about her work. Dr. Le is highly respected and sought after for her strong proficiency in judging the work and ideas of her peers. She is regularly invited to serve on review panels by prestigious organizations such as the National Institutes of Health and the US Department of Defense. She is frequently asked by high-cited scientific journals to review manuscripts submitted to their journals.

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

19.12.2018

Abbildungen

XV, 31 illus. in color., farbige Illustrationen

Herausgeber

Anne Le

Verlag

Springer

Seitenzahl

183

Maße (L/B/H)

23.5/15.5/1.2 cm

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-3-030-08525-4

Herstelleradresse

Springer International Publishing AG
Gewerbestr. 11
6330 Cham
Schweiz
Url: www.springer.com

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  • Produktbild: The Heterogeneity of Cancer Metabolism
  • A. The metabolism of cancer cells

    I. Glucose metabolism

    1. The Warburg Effect

    2. Up-regulation of glucose uptake

    3. Dysregulation of TCA cycle

    4. Dysregulation of pentose phosphate pathway

    5. Glycogen and gluconeogenesis

    5. Targeting glucose metabolism for cancer therapy

    II. Glutamine Metabolism

    6. Glutamine addiction

    7. TCA cycle fed solely by glutamine

    8. Reductive carboxylation

    9. Targeting glutamine metabolism for cancer therapy

    III. Amino acid metabolism

    10. Transaminase up-regulation

    11. Targeting amino acid synthesis for cancer therapy

    IV. Lipid metabolism

    12. Dysregulation of lipid metabolism in cancer

    13. Targeting lipid metabolism for cancer therapy

    V. Epigenetics and oncometabolites           

    B. Heterogeneity of Cancer Metabolism

    I. Specific oncogenic mutations lead to specific metabolic phenotypes within same tissue of origin

    14. Pancreatic cancer

    15. Glioblastomas

    16. Renal cell carcinomas

    17. Breast cancers

    18. Non-Hodgkin’s lymphoma

    II. Intratumoral heterogeneity of cancer cell metabolism

    19. Intratumoral genetic alterations leads to adaptive metabolic heterogeneity

    20. Different tumor microenvironments lead to different metabolic phenotypes

    III. Differential metabolism in vitro and in vivo



    C. Carcinoma associated fibroblasts (CAFs)

    21. Characteristics of CAFs

    22. Reverse Warburg effect

    23. Metabolic exchange between CAFs and cancer cells