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  • Produktbild: RNA, the Epicenter of Genetic Information
  • Produktbild: RNA, the Epicenter of Genetic Information

RNA, the Epicenter of Genetic Information A New Understanding of Molecular Biology

Fr. 159.00

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

20.09.2022

Abbildungen

schwarz-weiss Illustrationen, farbige Illustrationen, Raster, schwarz-weiss, Raster, farbig, Zeichnungen, schwarz-weiss, Zeichnungen, farbig, Tabellen, schwarz-weiss

Verlag

Taylor & Francis

Seitenzahl

422

Maße (L/B/H)

26/18.3/2.7 cm

Gewicht

980 g

Sprache

Englisch

ISBN

978-0-367-62392-0

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

20.09.2022

Abbildungen

schwarz-weiss Illustrationen, farbige Illustrationen, Raster, schwarz-weiss, Raster, farbig, Zeichnungen, schwarz-weiss, Zeichnungen, farbig, Tabellen, schwarz-weiss

Verlag

Taylor & Francis

Seitenzahl

422

Maße (L/B/H)

26/18.3/2.7 cm

Gewicht

980 g

Sprache

Englisch

ISBN

978-0-367-62392-0

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  • Produktbild: RNA, the Epicenter of Genetic Information
  • Produktbild: RNA, the Epicenter of Genetic Information

  • Preface
    Chapter 1 Overview
    • The genetic material?
    • Halcyon days
    • Worlds apart
    • Huge genomes, strange genetics
    • The age of Aquarius
    • All that junk
    • The expanding repertoire of RNA
    • Glimpses of a modern RNA world
    • Genome sequencing and transposable elements
    • The human genome
    • Small RNAs with mighty functions
    • Large RNAs with many functions
    • The epigenome
    • The programming of development
    • RNA and repeats rule
    • Plasticity
    • Beyond the jungle of dogmas
    Chapter 2 The genetic material?
    • The nature of matter
    • Sugars and fats
    • Proteins: ‘the locus of life’
    • Nucleic acids and chromosomes
    • Chromosomes as the mediators of genetic inheritance
    • The ‘Modern Synthesis’
    • Distinguishing DNA and RNA
    • One gene-one protein and the ‘nature of mutations’
    • DNA is the genetic material
    • The double helix – icon of the coming age
    Chapter 3 Halcyon days
    • The big question
    • Discovery of the ribosome
    • The messenger and the adaptor
    • The ‘genetic code’
    • The lac operon and gene regulation
    • Protein structure
    • The Central Dogma
    • It’s all over now
    Chapter 4 Worlds apart
    • The origin of cells
    • Genetic recombination
    • The emergence of complex organisms
    • Chromatin
    • Chromatin-associated RNA
    • Early models of RNAs in nuclear architecture
    • Heterogenous nuclear RNA
    • Heroes or fools?
    Chapter 5 Strange genomes, strange genetics
    • Repetitive DNA
    • Controlling elements
    • Paramutation, imprinting and transinduction
    • The bithorax ‘complex locus'
    • Transvection
    • Epigenetic modifiers
    • The Britten and Davidson model
    • Boolean models of combinatorial control
    • Processed RNAs as global regulators
    • Out on a limb
    Chapter 6 The Age of Aquarius
    • Recombinant DNA and ‘gene cloning’
    • Enabling technologies
    • DNA sequencing
    • The gold rushes
    • Hox genes
    • Oncogenes and tumor suppressors
    • Immunology and monoclonal antibodies
    • Biotechnological exploitation
    • Cell-free DNA amplification and shotgun cloning
    • A world of proteins
    Chapter 7 All that junk
    • The C-value enigma
    • Duplication and transposition
    • Mutational load, nonsense DNA, nonsense RNA
    • Neutral evolution
    • Conservation and selection
    • Junk DNA
    • Selfish DNA
    • Genes-in-pieces!
    • Not junk?
    Chapter 8 The expanding repertoire of RNA
    • Spliceosomal RNAs
    • Small nucleolar RNAs
    • Other small guide, scaffolding and regulatory RNAs
    • Catalytic RNAs and the ancient RNA World hypothesis
    • The catalytic heart of splicing and translation
    • The digital and analog faces of RNA
    • Candles in the dark
    Chapter 9 Glimpses of a modern RNA world
    • Riboregulators
    • Riboswitches
    • Antisense RNAs and complex transcription in eukaryotes
    • Long untranslated RNAs
    • UTR derived RNAs
    • First glimpses of small regulatory RNAs in animals
    • Curiosities or emissaries?
    Chapter 10 Genome sequences and transposable elements
    • Genome mapping
    • Genetics at genome scale
    • Whole genome sequencing of bacteria and archaea
    • Genome sequencing of unicellular eukaryotes
    • Genome sequencing of model plants and animals
    • The G-value enigma
    • Comparative genomics at nucleotide resolution
    • Pseudogenes and retrogenes
    • Transposable elements as functional modules
    • Transposable elements as drivers of phenotypic innovation
    • The great exploration – the diversity of life
    • From genome sequence to genome biology
    Chapter 11 The human genome
    • The project
    • Assessment of functionality
    • The majority of the genome is active
    • Damaged genes
    • A plethora of ‘rare’ diseases
    • Complex traits and disorders
    • The transformation of medical research and healthcare
    Chapter 12 Small RNAs with mighty functions
    • Unusual genetic phenomena involving RNA
    • The RNA interference pathway
    • Transcriptional gene silencing: RNA-directed DNA methylation
    • Research and biotechnology applications
    • MicroRNAs
    • Piwi-associated RNAs (piRNAs)
    • Other classes of small RNAs
    • RNA communication between species
    • CRISPR
    • RNA-directed genome editing
    Chapter 13 Large RNAs with many functions
    • Pervasive transcription
    • The amazing complexity of the transcriptome
    • Protein-coding or noise?
    • The restricted expression of long noncoding RNAs
    • Other indices of functionality of long noncoding RNAs
    • The genetic signatures of long noncoding RNAs
    • An avalanche of long noncoding RNAs
    • A plethora of functions
    • The Wild West
    Chapter 14 The epigenome
    • Chromatin structure
    • Topological domains
    • Enhancers
    • Nucleosomes and histones
    • Nucleosome remodeling
    • Histone modifications
    • The histone code
    • DNA methylation
    • The regulation of development
    Chapter 15 The programming of development
    • Autopoiesis
    • The overarching question
    • Tissue architecture and cell identity
    • Programmed ontogeny
    • Lineage specification
    • How much information is required?
    • Constraints imposed by the superlinear scaling of regulatory information
    • How much information is there in the human genome?
    • Genomes as .zip files of transcriptomes
    Chapter 16 RNA and repeats rule
    • RNA is a core component of chromatin
    • RNA and repeat regulation of chromosome structure
    • RNA guidance of chromatin remodeling
    • RNA guidance of sequence specific transcription factors
    • RNA guidance of DNA methylation
    • RNA guidance of histone modifications
    • Xist as the exemplar
    • Enhancer RNAs control chromatin structure
    • Intrinsically disordered proteins and RNA scaffolding of phase-separated domains
    • An addition to the ancient RNA world hypothesis
    • Structure-function relationships in lncRNAs
    • A new view of the genome of complex organisms
    Chapter 17 Plasticity
    • RNA modifications and the unknown epitranscriptome
    • The expansion of RNA editing in cognitive evolution
    • A>I editing
    • C>U editing
    • The brain
    • RNA-directed transgenerational epigenetic inheritance
    Chapter 18 Beyond the jungle of dogmas
    • The misunderstanding of molecular biology
    • The evolution of evolvability
    References