Pharmacokinetic study of solid dispersion tablet of Kariyat extract Pharmacokinetic, tissue distribution and stability study of solid dispersion tablet of Adrographis paniculata extract. DE
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- Englisch ausgewählt
Fr. 61.90
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
25.07.2022
Verlag
LAP LAMBERT Academic PublishingSeitenzahl
68
Maße (L/B/H)
22/15/0.5 cm
Gewicht
119 g
Sprache
Englisch
ISBN
978-620-5-48714-3
Andrographolide is poorly soluble in water, it has low oral bioavailability. Objective of present study was to enhance solubility of andrographolide through solid dispersion technique and conversion it into tablet dosage form. Solubility of extract was found to be more from solid dispersion prepared by using Soluplus than that of prepared using PEG 6000. Compatibility study using IR, DSC and XRD showed that, ethanolic extract is compatible with soluplus and can be used for preparation of stable formulation. Pharmacokinetic study showed that, there was a significant increase in absorption of andrographolide from solid dispersion tablet. andrographolide. The relative bioavailability of andrographolide from solid dispersion tablet to that of pure andrographolide was found to be 177.59±14.6%. From tissue distribution study it can be concluded that, concentration of andrographolide in all tissues get increased in animals in which solid dispersion tablet was administered orally. It reveals that absorption of andrographolide is getting increased after conversion of extract into solid dispersion tablet. Accelerated stability study indicates that prepared solid dispersion was stable.
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