Band 203
In Situ Detection of DNA Damage Methods and Protocols
Aus der Reihe
Methods in Molecular Biology
-
- Englisch ausgewählt
Fr. 138.00
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Gebundene Ausgabe
Erscheinungsdatum
30.04.2002
Abbildungen
XVII, 164 illus., 31 illus. in color., farbige Illustrationen, schwarz-weiss Illustrationen
Herausgeber
Vladimir V. DidenkoVerlag
Humana PressSeitenzahl
313
Maße (L/B/H)
24.1/16/2.5 cm
Gewicht
1 g
Auflage
2002
Sprache
Englisch
ISBN
978-0-89603-952-0
Detection and analysis of DNA damage is of critical importance in a variety of biological disciplines studying apoptosis, cell cycle and cell di- sion, carcinogenesis, tumor growth, embryogenesis and aging, neu- degenerative and heart diseases, anticancer drug development, environmental and radiobiological research, and others. Individual cells within the same tissue or in cell culture may vary in the extent of their DNA damage and, consequently, can display different re- tions to it. These differences between individual cells in the same cell popu- tion are detected using in situ approaches. In situ is a Latin term meaning “on site” or “in place.” It is used to denote the processes occurring or detected in their place of origin. In mole- lar and cell biology this usually refers to undisrupted mounted cells or tissue sections. In that meaning “in situ” is used as part of the terms “in situ PCR,” “in situ transcription,” “in situ hybridization,” “in situ end labeling,” and “in situ ligation.” Sometimes the “in situ” term is applied at the subcellular level to cells disrupted in the process of analysis, for example, in the detection of specific sequences in chromosomes using fluorescent in situ hybridization (FISH). Historically, the term was used primarily in methods dealing with nucleic acids.
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