Band 221
Contrast Agents I Magnetic Resonance Imaging
Aus der Reihe
Topics in Current Chemistry
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- Hardcover ausgewählt
- Taschenbuch
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Sprache:Englisch
Fr. 360.00
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Gebundene Ausgabe
Erscheinungsdatum
22.01.2002
Abbildungen
X, 21 illus., 2 illus. in color., schwarz-weiss Illustrationen, farbige Illustrationen
Herausgeber
Werner KrauseVerlag
Springer BerlinSeitenzahl
249
Maße (L/B/H)
24.1/16/2.1 cm
Gewicht
502 g
Auflage
2002
Sprache
Englisch
ISBN
978-3-540-42247-1
Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1–2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1].
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