Nguyen, K: Distribution of GLAST and Na+/K+-ATPase Activity

It has been known for many years that glutamate
system implicated in pathophysiology of several
mental illnesses. The molecular mechanisms of these
neurological disorders including stroke, ischemia,
schizophrenia and hepatic encephalopathy are poorly
understood. Therefore, this book analyzes the
distribution between astroglial membrane and
cytoplasm of glutamate transporter GLAST claimed to
be associated with its activity and focuses on the
activity of its coupling enzyme Na+/K+-ATPase. The
study examines the regulation of GLAST redistribution
in the presence of neuroleptic drugs, ammonia,
purinergic receptor activation and Na+/K+-ATPase
inhibitors and explores kinetics of Na+/K+-ATPase and
characteristics of rottlerin. The work covers
aspects of molecular and cellular biology, cell
imaging, pharmacology and biophysical chemistry.
This book intends to provide a general knowledge of
the field to the readers and highlights significances
of the current research with figures, graphs and
images. It is a useful source for researchers and
students interested in a wide range of disciplines.