Development of Self Microemulsifying Drug Delivery System Preparation and evaluation of Lovastatin Self Microemulsifying Drug Delivery System
-
- Englisch ausgewählt
Fr. 67.90
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
31.05.2011
Verlag
BoD - Books on DemandSeitenzahl
104
Maße (L/B/H)
22/15/0.7 cm
Gewicht
173 g
Auflage
1. Auflage
Sprache
Englisch
ISBN
978-3-8443-3182-0
Nearly 40% of new drug candidates exhibit low solubility in water, which leads to poor oral bioavailability, high intra- and inter-subject variability and lack of dose proportionality. Modification of the physicochemical properties, such as salt formation and particle size reduction of the compound may be one approach to improve the dissolution rate of the drug. However, these methods have their own limitations. In recent years, much attention has focused on lipid based formulations to improve the oral bioavailability of poorly water soluble drugs. In fact, the most popular approach is the incorporation of the drug compound into inert lipid vehicles such as oils, surfactant dispersions, self-emulsifying formulations, emulsions and liposomes with particular emphasis on self-microemulsifying drug delivery systems (SMEDDS).
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