Yadav, V: Molecular Signaling Pathways in Human Skin Carcino Loss of Tumor Suppressor Protein Kinase C Delta by Ras Oncogene, Fyn Tyrosine Kinase and NF-kappaB Signaling Pathway
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- Englisch ausgewählt
Fr. 95.90
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Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
27.07.2011
Verlag
LAP LAMBERT Academic PublishingSeitenzahl
192
Maße (L/B/H)
22/15/1.2 cm
Gewicht
302 g
Sprache
Englisch
ISBN
978-3-8454-1453-9
The delta isoform of Protein Kinase C (PKC-d) is a potential tumor suppressor gene for human squamous cell carcinomas (SCCs). The objective of this study is to investigate the mechanism of PKC-d loss in human SCCs. We used Laser Capture Microdissection to isolate cells for nucleic acid analysis from normal epidermises and human SCCs. Using this approach, we found that PKC-d is lost at the mRNA level in human SCCs, and that the PKC-d gene is rarely deleted suggesting that the mechanism of down-regulation of PKC-d in SCCs is at the level of gene transcription. Further investigation identified a novel Ras¿PI3K¿Fyn¿NF-¿B signaling pathway necessary and suffcicient for PKC-d repression in human keratinocytes. Our results have implications for the development of therapeutic strategies abrogating this signaling pathway to trigger the re-expression of pro-apoptotic PKC-d to induce apoptosis in SCCs.
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