Leucocyte Trafficking The Role of Fucosyltransferases and Selectins
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- Hardcover ausgewählt
- Taschenbuch
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Sprache:Englisch
Fr. 192.00
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Gebundene Ausgabe
Erscheinungsdatum
07.10.2003
Abbildungen
w. mit 47 Illustrationen
Herausgeber
A. Hamann + weitereVerlag
Springer BerlinSeitenzahl
242
Maße (L/B/H)
23.5/15.7/1.9 cm
Gewicht
462 g
Auflage
2004
Sprache
Englisch
ISBN
978-3-540-40112-4
An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.
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