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Produktbild: Quantitative Aspects of Allosteric Mechanisms
Band 28

Quantitative Aspects of Allosteric Mechanisms

Aus der Reihe Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik

Fr. 137.00

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

15.12.2011

Verlag

Springer Berlin

Seitenzahl

108

Maße (L/B/H)

24.4/17/0.7 cm

Gewicht

222 g

Auflage

Softcover reprint of the original 1st ed. 1978

Sprache

Englisch

ISBN

978-3-642-81233-0

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

15.12.2011

Verlag

Springer Berlin

Seitenzahl

108

Maße (L/B/H)

24.4/17/0.7 cm

Gewicht

222 g

Auflage

Softcover reprint of the original 1st ed. 1978

Sprache

Englisch

ISBN

978-3-642-81233-0

Herstelleradresse

Springer-Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE

Email: GPSR Kontakt

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  • Produktbild: Quantitative Aspects of Allosteric Mechanisms
  • 1 Basic Concepts of Allosteric Control.- 2 The Structure of Multisubunit Proteins.- I. General Principles.- II. Other Types of Protein Assemblies.- 3 Cooperativity in Multisubunit Proteins — The Basic Concepts.- I. The Hill Equation.- II. The General Adair Equation.- III. The Statistical Correction.- IV. The Hill Coefficient in Terms of Intrinsic Ligand Affinities.- V. The Hill Coefficient at 50% Ligand Saturation.- VI. The Maximal Hill Coefficient.- VII. The Limiting Values of the Hill Slope.- VIII. The Allosteric Dimer.- IX. The Multi-Dimer Case.- X. The Allosteric Tetramer.- XI. The General Tetrameric Case.- 4 The Energy of Subunit Interactions.- I. Determination of Intersubunit Interaction Energy.- II. The Hill Coefficient and the Intersubunit Interaction Energy.- III. The Meaning of Intersubunit Energy of Interaction.- 5 Molecular Models for Cooperativity and Allosteric Interactions.- I. Introduction.- II. The Monod-Wyman-Changeux (MWC) Concerted Model.- 1. Basic Assumptions of the Concerted Model.- 2. The Allosteric Dimer Analyzed by the MWC Model.- 3. Allosteric Inhibition and Allosteric Activation in the MWC Model.- 4. The General Case.- 5. Phenomena Explained by the Concerted Model.- 6. Cooperativity in the Monod-Wyman-Changeux Model.- III. The Koshland-Némethy-Filmer (KNF) Sequential Model.- 1. Basic Assumptions of the Sequential Model.- 2. The Allosteric Dimer Analyzed by the KNF Model.- 3. Allosteric Activation and Allosteric Inhibition in the KNF Model — the Dimer Case.- 4. The KNF Model — the Tetramer Case.- 5. The Influence of the Intersubunit Binding Domains on the Nature of Subunit Interactions.- IV. The Conformational State of the Protein.- 1. Exclusive Binding in the MWC Model.- 2. The Nonexclusive Binding in the MWC Model.- 3. The Simple Sequential KNF Model.- 4. The General Sequential KNF Model.- 5. Measuring R?.- V. Comparison Between the KNF Model and the MWC Model.- 6 Special Types of Cooperative Systems.- I. Cooperativity Resulting from Ligand-Coupled Protein Association or Dissociation.- 1. Ligand-Coupled Monomer-Dimer Equilibrium.- 2. The General Case.- II, Negative Cooperativity.- III. Protein Association and Dissociation Coupled to Ligand Binding.- 1, Dimerization Coupled to Ligand Binding.- 2. Monomer Multimer Equilibrium Coupled to Ligand Binding.- References.