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  • Produktbild: Teratogenesis and Reproductive Toxicology
  • Produktbild: Teratogenesis and Reproductive Toxicology
Band 65

Teratogenesis and Reproductive Toxicology

Aus der Reihe Handbook of Experimental Pharmacology

Fr. 137.00

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

08.12.2011

Herausgeber

E.M. Johnson + weitere

Verlag

Springer Berlin

Seitenzahl

372

Maße (L/B/H)

24.4/17/2.2 cm

Gewicht

675 g

Auflage

Softcover reprint of the original 1st ed. 1983

Sprache

Englisch

ISBN

978-3-642-81921-6

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

08.12.2011

Herausgeber

Verlag

Springer Berlin

Seitenzahl

372

Maße (L/B/H)

24.4/17/2.2 cm

Gewicht

675 g

Auflage

Softcover reprint of the original 1st ed. 1983

Sprache

Englisch

ISBN

978-3-642-81921-6

Herstelleradresse

Springer-Verlag KG
Sachsenplatz 4-6
1201 Wien
AT

Email: GPSR Kontakt

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  • Produktbild: Teratogenesis and Reproductive Toxicology
  • Produktbild: Teratogenesis and Reproductive Toxicology
  • Epidemiology and Bioavailability.- 1 Assessment of Potential Hazards to the Unborn in the Workplace.- A. Introduction.- B. Management of the Hazard.- C. Environmental Agents.- D. Protective Measures.- E. Safety Standards.- F. Summary.- References.- 2 Pharmacokinetic Modeling and the Teratologist.- A. Introduction.- B. Pharmacokinetic Modeling and Simulation.- I. One-Compartment Open Model.- II. One-Compartment Model with Parallel Elimination.- III. One-Compartment Absorption Model.- C. Multicompartment Models.- I. Two-Compartment Model.- II. Protein Binding and Metabolism Models.- III. Drug-Chemical Interactions (Blood Protein and Tissue Binding).- D. Data Acquisition and Analysis.- References.- 3 Placental Drug Metabolism.- A. Introduction.- B. Oxidation Reactions.- I. Dehydrogenases.- II. Monoamine Oxidase.- III. Monooxygenases.- C. Reduction Reactions.- D. Hydrolytic Reactions.- E. Conjugation Reactions.- References.- 4 Genetic Differences in Drug Metabolism: Proposed Relationship to Human Birth Defects.- A. Introduction.- I. Phase I and Phase II Drug-Metabolizing Enzymes.- II. Fundamental Aspects of Cytochrome P-450.- III. Assessment of Substrates Metabolized by Cytochrome P-450.- B. The Ah Locus.- I. Genetics.- II. Pleiotypic Response of the Ah System.- C. Genetic Influences on Drug-Induced Birth Defects.- D. Use of Ah Locus for Teratogenesis Studies.- I. Genetic Differences in BaP Teratogenicity.- II. Correlation of BaP-Induced Stillbirths and Resorptions with the Ah Allele.- III. Association of BaP-Induced Embryotoxicity with the Ah Allele.- IV. Correlation of BaP-Induced Teratogenesis with the Ah Allele.- V. Developmental Expression of Ah Allele in the Mouse Embryo.- E. Extrapolation of Data to the Human.- F. Summary.- References.- Mechanisms of Teratogenesis.- 5 Viruses as Teratogens.- A. Introduction.- B. Discussion.- I. Epidemiology.- II. Rubella Virus.- III. Cytomegalovirus.- IV. Herpes Simplex Virus.- V. Venezuelan Equine Encephalitis Virus.- VI. Varicella Virus.- C. Summary.- References.- 6 Hormonal Involvement in Palatal Differentiation.- A. Introduction.- B. Developmental Aspects of Secondary Palate Formation.- C. Cyclic AMP and Palatal Differentiation.- D. Prostaglandins in the Secondary Palate.- E. Summary.- References.- 7 Membrane Lipids and Differentiation.- A. Introduction.- B. Membrane Lipid Composition and Differentiation.- C. Lipids as Intracellular Messengers.- D. Membrane Lipid Metabolism During Normal and Abnormal Mammalian  Embryogenesis.- I. Initial Studies.- II. Role of the Placenta.- III. Experimental Approaches.- IV. Results.- 1. In Vitro Enzyme Studies.- 2. In Vivo Metabolic Studies.- 3. In Vitro Metabolic Studies.- 4. Acyl Composition of Embryo and Placental Phospholipids.- V. Vitamin A and Glucocorticoids.- E. Conclusion.- References.- 8 Hormone Receptors and Malformations.- A. Introduction.- B. Steroids.- I. Androgens.- 1. Testicular Feminization.- II. Glucocorticoids.- 1. Cystic Fibrosis.- 2. Cleft Palate.- C. Cholesterol.- I. Low Density Lipoprotein.- 1. Familial Hypercholesterolemia.- D. Thyroid Hormones.- I. Triiodothyronine.- 1. Familial Thyroid Hormone Resistance.- E. Polypeptide Hormones.- I. Growth Hormone.- 1. Levi-Lorain Dwarfism and Snell Dwarf.- II. Parathyroid Hormone.- 1. Pseudohypoparathyroidism.- F. Conclusion.- References.- 9 Mutagens as Teratogens: A Correlative Approach.- A. Introduction.- B. In Vivo Cytogenetics Versus Teratology.- C. In Vitro Cytogenetics Versus Teratology.- D. Teratogenicity and Microtubule Disruption.- E. Carcinogens as Mutagens and Teratogens.- F. Discussion.- I. Teratology Correlated with Chromosome Alteration.- II. Teratology Correlated with Carcinogen-Induced Point Mutations.- III. Mutation and Abnormal Development.- References.- Adverse Effects on Function.- Chpater 10 Behavioral Testing Procedures: A Review.- A. Introduction.- B. Morphological Development of the Central Nervous System.- C. Variables in Behavioral Teratologic Testing.- I. Examples of Behavioral Teratogens.- II. Premating and Prenatal Variables.- III. Postnatal Variables.- D. Postnatal Assessment.- I. Physical Development.- 1. Pinna Detachment.- 2. Incisor Eruption.- 3. Eye Opening.- 4. Ear Unfolding and Opening.- 5. Testes Descent.- 6. Vaginal Opening.- 7. Development of Fur.- II. Behavioral Analyses.- 1. Reflex Development Tests.- 2. Motor and Coordination Tests.- 3. Spontaneous or Nonforced Behavior Tests.- 4. Forced Behavioral Tests.- E. Conclusions.- References.- 11 Behavioral Teratology: A New Frontier in Neurobehavioral Research.- A. Introduction.- B. Agents that Cause Gross Structural Malformation and Behavioral Effects.- I. Animal Studies and the Consideration of Critical Periods.- 1. Predifferentiation Period.- 2. Period of the Embryo.- 3. Period of the Fetus.- II. Human Studies.- 1. The Fetal Alcohol Syndrome.- 2. The Fetal Hydantoin Syndrome.- 3. The Fetal Trimethadione Syndrome.- 4. Thalidomide.- C. Agents that Cause Behavioral Effects in the Absence of Gross Structural Malformations.- I. Animal and Human Studies.- 1. Amphetamine.- 2. Barbiturates.- 3. Phencyclidine.- 4. Opiates.- D. Summary.- References.- 12 Abnormal Lung Function Induced by Prenatal Insult.- A. Introduction.- B. Lung Development.- C. Experimental Alteration of Lung.- D. Impact and Visibility of Developmental Alterations in Neonatal Population.- E. Conclusion.- References.- 13 Postnatal Alterations of Gastrointestinal Physiology, Hematology, Clinical Chemistry, and Other Non-CNS Parameters.- A. Introduction.- B. Functional Teratology of the Gastrointestinal Tract.- I. Gastrointestinal Congenital Malformations.- II. Normal Anatomy, Development, and Physiology of the Gastrointestinal Tract.- III. Physiologic Teratology of the Gastrointestinal Tract.- IV. Test Agents.- V. Observations.- 1. Anatomic.- 2. Rectal Emptying.- 3. Transit Time.- 4. Food Consumption and Utilization.- 5. Gastric Emptying.- VI. Discussion of Observed Physiologic Changes.- C. Other Non-CNS Functional Alterations.- I. Hematology.- II. Clinical Chemistry.- III. Urinalysis.- IV. Reproduction.- V. Cardiovascular.- VI. Organ Weights.- VII. Histopathology.- VIII. Immunology.- D. Summary and Conclusion.- References.- In Vitro Screens of Teratogenic Potential.- 14 Detection of Teratogens Using Cells in Culture.- A. Introduction.- B. Differentiating Cells in Culture to Detect Teratogens.- C. In Vitro Cell Interactions.- D. Migration of Cells in Culture.- E. Conclusions.- References.- 15 Embryonic Organs in Culture.- A. Introduction.- B. Advantageous Features of In Vitro Systems.- C. Developmental Features of the Limb Bud.- D. Limb Bud Organ Culture.- I. General.- II. Details of the Culture Method.- III. Characteristics of the Cultured Limb Buds.- IV. Quantification of Cartilage in Cultures.- V. The Use and Efficacy of the Screening System.- VI. Summary.- E. Current Limitations and Future Improvements.- F. Conclusions.- References.- 16 Whole Embryos in Culture.- A. Introduction.- B. Preimplantation.- I. General Considerations.- II. The All-or-None Response.- C. Peri-Implantation.- I. General Considerations.- II. Technical Obstacles.- III. Blastocyst Cultures.- D. Postimplantation.- I. Direct Additions.- 1. Chemical Inhibitors.- 2. Environmental Factors.- 3. Substances Implicated in Human Exposure.- II. Beyond Direct Additions.- 1. Chemical Inhibitors.- 2. Heavy Metals.- 3. Nutrition.- III. Metabolic Activation.- IV. Teratogen Identification.- 1. Diabetes.- 2. Immunologic Responses.- 3. Fetal Wastage.- References.- 17 The Role of an Artificial Embryo in Detecting Potential Teratogenic Hazards.- A. Introduction.- B. Basic Aspects of Hydra Biology.- I. Nurture of Adult Hydra.- II. The Nature of Artificial Hydra “Embryos”.- 1. The Testing Procedure.- a) “Embryos”.- b) Adult Hydra.- C. Evaluation of Results.- D. Discussion.- References.- Chemical Index.