Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
31.07.2012
Abbildungen
20 schwarzweisse Abbildungen, 8 Tabellen
Herausgeber
Michael L.G. Gardner + weitereVerlag
SpringerSeitenzahl
96
Maße (L/B/H)
23.5/15.5/0.6 cm
Gewicht
176 g
Auflage
Softcover reprint of the original 1st ed. 1995
Sprache
Englisch
ISBN
978-3-642-79513-8
A large number of clinical studies have already been conducted in which animal serine and vegetable cysteine proteinases and combination preparations of them for oral use have been shown to arrest and heal acute and chronic inflammation. The pharmacodynamics and pharmacokinetics of these preparations are still a matter of controversy, however, because it is difficult to determine the absorption of these active substances. Experiments have produced false-positive and false-negative results no matter which procedure is used. The heterogeneity of knowledge within this field prompted a symposium, held in 1993 in Munich. This volume contains the findings of this meeting and does away with old dogmas - enzymes can indeed be absorbed! This book is a compilation of papers that arose from a multidisciplinary workshop held at the Walter-Straub-Institute for Pharmacology and Toxicology in Munich in September 1993 to review the current state fo knowledge relating to the oral administration of enzymes, especially proteases, as therapeutic agents. Issues such as the gastrointestinal absorption of intact macromolecules and the efficacy of oral enzyme preparations have been critically discussed, and areas requiring further investigation have been identified. This is the first time that objective information on this topic has been collected together from so many relevant disciplines. While absorption of intact proteins is now a proven phenomenon, its exploitation in therapeutics is still in its infancy, and this book should provide a sound scientific background for such applications and for further research.
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