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  • Produktbild: Morphogenesis of Thyroid Follicles in Vitro
  • Produktbild: Morphogenesis of Thyroid Follicles in Vitro

Morphogenesis of Thyroid Follicles in Vitro

Aus der Reihe Advances in Anatomy, Embryology and Cell Biology

Fr. 72.90

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

01.06.1976

Verlag

Springer Berlin

Seitenzahl

66

Maße (L/B/H)

23.5/15.5/0.5 cm

Gewicht

119 g

Sprache

Englisch

ISBN

978-3-540-07654-4

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

01.06.1976

Verlag

Springer Berlin

Seitenzahl

66

Maße (L/B/H)

23.5/15.5/0.5 cm

Gewicht

119 g

Sprache

Englisch

ISBN

978-3-540-07654-4

Herstelleradresse

Springer-Verlag KG
Sachsenplatz 4-6
1201 Wien
AT

Email: GPSR Kontakt

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  • Produktbild: Morphogenesis of Thyroid Follicles in Vitro
  • Produktbild: Morphogenesis of Thyroid Follicles in Vitro
  • Material and Methods.- Cultures.- Electron Microscopy.- Results.- I. Freshly Dissociated Cells.- A. The Isolated Cells.- B. The Fragments of the Follicle Epithelium.- II. Unreassociated Cells.- A. Control Cells after 15 min Culture.- B. Control Cells after 4 or More Days in Culture.- III. The Reassociated Cells.- A. Small Aggregates.- B. The Early Follicle.- C Ultrastructural Modifications of the Reassociated Cells.- D. Growth of the Follicle.- E. The Cells Reassociated after Several Days of Culture.- IV. Other Elements in the Culture.- A. The C Cells.- B. Connective Tissue Components.- C. Basal Lamina.- Discussion.- I. Biochemical Aspects of Follicular Reassociation in Cultured Thyroid Cells.- A. Reaggregation of Dissociated Cells: General Review of Known Biological Systems.- 1. The Example of Dictyostelium Discoideum.- 2. Reaggregation Mechanisms.- a) In Dictyostelium Discoideum.- b) In Other Species.- c) The Specificity of Aggregation Promoting Factors.- 3. Mechanisms of Cell Adhesion.- a) In Dictyostelium Discoideum.- b) In Other Species.- B. Reaggregation and Reassociation of Isolated Thyroid Cells.- 1. Analogy with Known Systems.- a) Reaggregation Promoting Factor.- b) Cellular Adhesion and Metabolic Activity.- 2. Role of TSH in Reaggregation and Follicular Reassociation in Vitro.- a) Data from the Literature.- b) Reasons for these Contradictions.- c) Conclusion.- 3. Other Factors that Could Be Responsible for Follicular Morphogenesis in Vitro.- a) Endogenous TSH.- b) 3?-5? Cyclic AMP (cAMP).- c) Other Thyroid Molecules.- d) Connective Tissue Elements.- e) Calf Serum.- 4. Conclusion.- II. Ultrastructural Aspects of Follicular Reassociation.- A. Cells after Trypsinization.- 1. Plasmalemma Modifications.- 2. Cytoplasmic Modifications.- B. Follicular Reassociation.- 1. Reconstitution of the Cell Junctions.- a) Cell Contacts.- b) Zonula Occludens.- c) Adult Junctional Complex.- d) The Problem of Reconstitution of Cell Polarity.- 2. Cytoplasmic and Nuclear Modifications.- 3. Morphogenesis of the Microvilli.- 4. Nature of the Dense Follicular Material.- a) Ultimobranchial Colloid.- b) Immature Thyroglobulin.- c) Thyroglobulin Modified by the Processing for Electron Microscopy.- d) Cell Catabolism Products.- e) Membrane Glycoproteins or “Cell Coat”.- 5. Morphogenesis of Cilia.- 6. Growth of the Follicle.- 7. The Role of Hydrocortisone.- III. The Origin of the Follicular Lumen.- A. Hypothesis for the Formation of the Follicular Lumen from Intracytoplasmic Cavities.- 1. Review of the Work by Light Microscopy.- 2. Review of the Work in Electron Microscopy.- B. Hypothesis of the Formation of the Follicular Lumen from the Intercellular Space Partitioned by an Annular Zonula Occludens.- 1. Review of the Literature.- 2. Proofs Supporting this Hypothesis.- a) Study of Ultrathin Serial Sections.- b) Study of Follicular Models (Figure 15).- IV. Comparative Arguments Supporting the Extracellular Origin of the Follicular Lumen.- A. Phylogenic Development of the Thyroid Gland.- 1. Formation and Histology of the Lamprey Endostyle (Subpharyngeal Gland).- 2. Appearance of the Thyroid Gland.- B. General Cytologic Aspects of Differentiation of Epithelia.- 1. Data Relevant to the Problem.- 2. Reaggregation of Dissociated Embryonic Cells.- 3. Development of the Blood Capillaries.- 4. Morphogenesis of Kidney Glomeruli and Tubules.- 5. Organogenesis and Histogenesis of the Pancreas.- 6. Morphogenesis of the Biliary Canaliculi of the Liver Parenchyme.- 7. Development of Gastric Oxyntic Cells.- 8. Conclusion.- Summary.- Acknowledgements.- References.