Band 166
Transcription Factors
Aus der Reihe
Handbook of Experimental Pharmacology
-
- Hardcover
- Taschenbuch ausgewählt
- eBook
-
Sprache:Englisch
-
Verlag:Springer Berlin
Fr. 360.00
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
17.08.2012
Herausgeber
Manfred Gossen + weitereVerlag
Springer BerlinSeitenzahl
581
Maße (L/B/H)
23.5/15.5/3.2 cm
Gewicht
890 g
Auflage
Softcover reprint of the original 1st ed. 2004
Sprache
Englisch
ISBN
978-3-642-62361-5
Transcription factors are key players in the execution of the genomic program of any given cell. Their control over complex patterns of gene expression governs essentially every step in the development, growth and differentiation of an organ ism as well as its physiological responses to external stimuli. An Introduction to Transcription Factors, the first part of this volume, de scribes the varied and combinatorial mechanisms involved in the two basic modes of transcriptional control, activation (the chapter by Herrera et al.) and repression (the chapter by Arnosti). Overlaying both modes is an emerging emphasis on epigenetic regulation that uses intricate patterns of chromatin modi fication. Although many of these mechanisms have been elucidated by studying prototypical genes or transcription factors, the recently developed tools of ge nomic biology allow us to unravel the complexity of global transcriptional pro grams with an ever-increasing speed and accuracy (the chapter by Zacharewski and La Pres). Given the central role that transcription factors playas relays positioned be tween the genome and the intracellular and extracellular signals to which cells must respond, it is not surprising that these regulatory proteins playa major role in pathological processes. Part 2 of this volume, Transcription Factors in Patho physiology, introduces a selection of specific transcription factors and their families. Each of these factors has a well-established function in basic cellular mechanisms that, upon dysregulation, can cause or contribute to human disease.
Noch keine Bewertungen vorhanden
Verfassen Sie die erste Bewertung zu diesem Artikel
Helfen Sie anderen Kundinnen und Kunden durch Ihre Meinung.