Introduction - Stephen Neidle
Foreword - Hilary Calvert
Part I. Basic Principles and methodology
Modern cancer drug discovery: integrating targets, technologies and treatments - Paul Workman and
Ian Collins
Pharmacogenomics and personalised medicines in cancer treatment - Wei-Peng Yong, Ross Soo and
Federico Innocenti
Structural biology and anticancer drug design - Puja Pathuri, David Norton, Henriette Willems,
Dominic Tisi and Harren Jhoti
Part II. Drugs in the laboratory and clinic
Temozolomide: from cytotoxic to molecularly-targeted agent - Malcolm Stevens
Temozolomide: patents and the perils of invention - Malcolm Stevens
A new generation of cell-targeted drugs for cancer treatment - Paola B. Arimondo, Nicolas Guilbaud
and Christian Bailly
Inhibition of DNA repair as a therapeutic target - Stephany Veuger and Nicola J Curtin
Inhibitors of tumour angiogenesis - Adrian L. Harris and Daniele G Generali
The Renaissance of CYP17 Inhibitors for the Treatment of Prostate Cancer - Qingzhong Hu and Rolf
W. Hartmann
Apoptosis in Cancer: Mechanisms, Deregulation and Therapeutic Targeting - Zahid H Siddik
Targeting the MDM2-p53 protein-protein interaction: design, discovery and development of novel
anticancer agents - Ian R Hardcastle
Targeting altered metabolism - emerging cancer therapeutic strategy - Minsuh Seo, Robert Blake
Crochet and Yong-Hwan Lee
Inhibitors of the Phosphatidylinositol 3-kinase (PI3K) Pathway - William A Denny and Gordon W.
Rewcastle
Antibody-drug conjugates delivering DNA cytotoxics - John A Hartley
Inhibition of telomerase: promise, progress and potential pitfalls - Christopher G. Tomlinson, Scott B.
Cohen and Tracy M. Bryan
Targeting B-RAF: the discovery and development of B-RAF inhibitors - Phillip A Harris
Part III. The reality of cancer drugs in the clinic
Failure Modes in Anticancer Drug Discovery and Development - Richard A. Walgren and
Christopher. A. Slapak
Anticancer drug registration and regulation: current challenges and possible solutions - David
Taylor, Erling Donnelly and Silvia Chioato