Clinical Bioinformatics

1. From the Phenotype to the Genotype via Bioinformatics

Cali E. Willet and Claire M. Wade

2. Production and Analytic Bioinformatics for Next-Generation DNA Sequencing

Richard James Nigel Allcock

3. Analyzing the Metabolome

Francis G. Bowling and Mervyn Thomas

4. Statistical Perspectives for Genome-Wide Association Studies (GWAS)

Jennifer H. Barrett, John C. Taylor and Mark M. Iles

5. Bioinformatics Challenges in Genome-Wide Association Studies (GWAS)

Rishika De, William S. Bush, and Jason H. Moore

6. Studying Cancer Genomics through Next-Generation Sequencing and Bioinformatics

Maria A. Doyle, Jason Li, Ken Doig, Andrew Fellowes, and Stephen Q. Wong

7. Using Bioinformatics Tools to Study the Role of microRNA in Cancer

Fabio Passetti, Natasha Jorge, and Alan Durham

8. Chromosome Microarrays in Diagnostic Testing: Interpreting the Genomic Data

Greg B. Peters and Mark D. Pertile

9. Bioinformatics Approach to Understanding Interacting Pathways in Neuropsychiatric Disorders

Ali Alawieh, Zahraa Sabra, Amaly Nokkari, Atlal El-Assaad, Stefania Mondello, Fadi Zaraket, Bilal Fadlallah, and Firas H. Kobeissy

10. Pathogen Genome Bioinformatics

Vitali Sintchenko and Michael P.V. Roper

11. Setting Up Next-Generation DNA Sequencing in the Medical Laboratory

Bing Yu

12. Managing Incidental Findings in Exome Sequencing for Research

Marcus J. Hinchcliffe

13. Approaches for Classifying DNA Variants Found by Sanger Sequencing in a Medical Genetics Laboratory

Pak Leng Cheong and Melody Caramins

14. Designing Algorithms for Determining Significance of DNA Missense Changes

Sivakumar Gowrisankar and Matthew S. Lebo

15. DNA Variant Databases: Current and Future Directions

John-Paul Plazzer and Finlay Macrae

16. Natural Language Processing Systems in Biomedicine: A Unified System Architecture Overview

Son Doan, Mike Conway, Tu Minh Phuong, and Lucila Ohno-Machado

17. Candidate Gene Discovery and Prioritization in Rare Diseases

Anil G. Jegga

18. Computer Aided Drug Designing

Mohini Gore and Neetin S. Desai