HIV-Protease Inhibitory & Antidiabetic Activities of Natural Products Indian Medicinal Plants, Mangrove Plants and Shilajit
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- Englisch ausgewählt
Fr. 47.90
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
12.05.2014
Verlag
LAP LAMBERT Academic PublishingSeitenzahl
100
Maße (L/B/H)
22/15/0.7 cm
Gewicht
167 g
Sprache
Englisch
ISBN
978-3-659-54158-2
Ethanolic & aqueous extracts of Ocimum sanctum, Tinospora cordifolia, Withania somnifera, Avicennia officinalis, Rhizophora mucronata & Shilajit were included in the present in vitro study. Pepsin was used as a substitute for HIV-protease to evaluate effect of these extracts, as pepsin has great structural and functional similarities with HIV-protease. Pepsin assay could be used for preliminary screening of natural products for probable HIV-protease inhibitory activity. The use of combination antiretroviral therapy has yielded clinical benefits for HIV-infected patients, however, it has also led to adverse metabolic effects such as diabetes & when HIV & diabetes intersect, the treatment regimens required for both diseases can be overwhelming for patients. Hence, these extracts were further evaluated for their antidiabetic effect using alpha-Amylase & alpha-Glucosidase enzymes. O. sanctum, T. cordifolia, R. mucronata & Shilajit exhibited putative HIV-protease inhibitory activitiy. Further, O. sanctum & R. mucronata strongly inhibited alpha-Glucosidase enzyme, whereas, Shilajit potently inhibited both the carbohydrate hydrolyzing enzymes. Thus they showed antidiabetic potential also.
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