1-Amino-2-phenylethane derived sulfonamides 1-Amino-2-phenylethane derived sulfonamides as possible candidates for Alzheimer's Disease
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- Englisch ausgewählt
Fr. 55.90
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Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
16.09.2014
Verlag
LAP LAMBERT Academic PublishingSeitenzahl
60
Maße (L/B/H)
22/15/0.5 cm
Gewicht
107 g
Sprache
Englisch
ISBN
978-3-659-60635-9
The presented study encompasses the synthesis of a series of sulfonamides derivatives of 1-amino-2-phenylethane in excellent yield by reaction with various aryl sulfonyl chlorides, in the presence of aqueous sodium carbonate solution under dynamic pH control. These projected structures of the synthesized derivatives were characterized by IR, 1H-NMR and EIMS spectral techniques. Moreover, the screening of derivatives against acetyl cholinesterase (AChE), butyryl cholinesterase (BChE) and lipoxygenase (LOX) enzymes rendered these molecules as potent inhibitors of cholinesterase enzymes, relative to Baicalein and Eserine, which were used as reference standard.
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