Synthesis and characterization of nateglinide derivatives Synthesis and characterization of nateglinide derivatives
-
- Englisch ausgewählt
Fr. 74.90
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
08.08.2015
Verlag
LAP LAMBERT Academic PublishingSeitenzahl
96
Maße (L/B/H)
22/15/0.7 cm
Gewicht
161 g
Sprache
Englisch
ISBN
978-3-659-76920-7
A series of seven nateglinide analogues were synthesized successfully using 4-isopropyl cyclohexyl carboxylic acid (trans acid) as starting material, react with thionyl chloride and formed trans-4-isopropyl cyclohexane carbonyl chloride (trans acid chloride) as an intermediate which further reacted with D-phenylalanine to yield nateglinide. The derivatives were synthesized by reacting nateglinide and ethylchloroformate, and formed an unstable mix anhydride compound, which further react with primary and secondary amines to yield the nateglinide derivatives. All these molecules were characterized spectroscopically by mass spectra, IR, 1H NMR.
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