Band 221
Disordered Vertebral and Rib Morphology in Pudgy Mice Structural Relationships to Human Congenital Scoliosis
Aus der Reihe
Advances in Anatomy, Embryology and Cell Biology
-
- Taschenbuch ausgewählt
- eBook
-
Sprache:Englisch
Fr. 138.00
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
30.09.2016
Abbildungen
IX, 20 illus., 15 illus. in color., farbige Illustrationen, schwarz-weiss Illustrationen
Verlag
SpringerSeitenzahl
123
Maße (L/B/H)
23.6/15.4/1 cm
Gewicht
219 g
Auflage
1st ed. 2016
Sprache
Englisch
ISBN
978-3-319-43149-9
This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.
Noch keine Bewertungen vorhanden
Verfassen Sie die erste Bewertung zu diesem Artikel
Helfen Sie anderen Kundinnen und Kunden durch Ihre Meinung.